Neuroprotection trials in traumatic brain injury

S Chakraborty, B Skolnick, RK Narayan - Current neurology and …, 2016 - Springer
Traumatic brain injury (TBI) is a significant cause of mortality and morbidity worldwide.
Current treatment of acute TBI includes surgical intervention when needed, followed by …

Neuroprotection for traumatic brain injury

DJ Loane, BA Stoica, AI Faden - Handbook of clinical neurology, 2015 - Elsevier
Traumatic brain injury (TBI) is a major cause of mortality and morbidity worldwide. Despite
extensive preclinical research supporting the effectiveness of neuroprotective therapies for …

A review of neuroprotection pharmacology and therapies in patients with acute traumatic brain injury

KW McConeghy, J Hatton, L Hughes, AM Cook - CNS drugs, 2012 - Springer
Traumatic brain injury (TBI) affects 1.6 million Americans annually. The injury severity
impacts the overall outcome and likelihood for survival. Current treatment of acute TBI …

Emerging treatments for traumatic brain injury

Y Xiong, A Mahmood, M Chopp - Expert opinion on emerging drugs, 2009 - Taylor & Francis
Background: This review summarizes promising approaches for the treatment of traumatic
brain injury (TBI) that are in either preclinical or clinical trials. Objective: The …

Critical appraisal of neuroprotection trials in head injury: what have we learned?

CM Tolias, MR Bullock - NeuroRx, 2004 - Springer
To date, despite very encouraging preclinical results, almost all phase II/III clinical
neuroprotection trials in traumatic brain injury (TBI) have failed to show any consistent …

Targets of neuroprotection and review of pharmacological interventions in traumatic brain injury

MI Hiskens - Journal of Pharmacology and Experimental …, 2022 - ASPET
Traumatic brain injury (TBI) is a major contributor to disability and death worldwide, and
manifests in cognitive, behavioral, and motor impairment. Although there have been …

Recent developments in clinical trials for the treatment of traumatic brain injury

DG Stein, RI Geddes, EA Sribnick - Handbook of clinical neurology, 2015 - Elsevier
The clinical understanding of traumatic brain injury (TBI) and its manifestations is beginning
to change. Both clinicians and research scientists are recognizing that TBI and related …

Neuroprotective agents in traumatic brain injury

AIR Maas - Expert opinion on investigational drugs, 2001 - Taylor & Francis
The role of neuroprotection in traumatic brain injury (TBI) is reviewed. Basic research and
experimental investigations have identified many different compounds with potential …

Design of acute neuroprotection studies

GWJ Hawryluk, MR Bullock - Handbook of clinical neurology, 2015 - Elsevier
Traumatic brain injury (TBI) is a substantial public health problem. The discovery of
progressive, ongoing damage to the brain by means of complex molecular mechanisms …

Neuroprotection in traumatic brain injury: a complex struggle against the biology of nature

JW Schouten - Current opinion in critical care, 2007 - journals.lww.com
Traumatic brain injury is a complex disease, and development of clinically effective
neuroprotective agents is a difficult task. Experimental traumatic brain injury has provided …