Objectives: Multimodal analgesia is widely advocated for the control of perioperative pain in
an effort to reduce the use of opioid. Duloxetine is a selective inhibitor of serotonin and …

Objective This study describes a single-site investigation on the effects of a randomized
double-blind placebo trial targeting duloxetine added to opioid use (duloxetine+ opioid) …

Background Duloxetine is currently approved for chronic pain management; however,
despite some evidence, its utility in acute, postoperative pain remains unclear Aim of the …

Background Multimodal analgesia is advocated for perioperative pain management to
reduce opioid use and its associated adverse effects. Serotonin and norepinephrine are …

Objective: We aimed to evaluate the analgesic efficacy as well as the postoperative quality
of recovery of preoperative oral duloxetine a serotonin and norepinephrine reuptake …

Background Multimodal analgesia is a fundamental part of modern surgery and enhanced
recovery pathways. Duloxetine, a serotonin and norepinephrine reuptake inhibitor, has been …

Background Duloxetine administered during the acute perioperative period has been
associated with lesser postoperative pain and analgesic consumption. Study objectives The …

Background Duloxetine is an antidepressant that is also useful in chronic neuropathic and
central origin pain. In this study, the role of duloxetine in decreasing acute postoperative …

Study objective To test the hypothesis that duloxetine reduces postoperative morphine
consumption and pain intensity in patients undergoing major colonic surgeries. Design …

Background Pain is one of the most challenging issues following surgery, and it is crucial to
provide adequate and appropriate pain control measures. Objectives This study assessed …