Deep Resequencing Unveils Genetic Architecture of ADIPOQ and Identifies a Novel Low-Frequency Variant Strongly Associated With Adiponectin Variation
Increased adiponectin levels have been shown to be associated with a lower risk of type 2
diabetes. To understand the relations between genetic variation at the adiponectin-encoding …
diabetes. To understand the relations between genetic variation at the adiponectin-encoding …
[HTML][HTML] Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are
highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other …
highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other …
Common Variants in the Adiponectin Gene (ADIPOQ) Associated With Plasma Adiponectin Levels, Type 2 Diabetes, and Diabetes-Related Quantitative Traits: The …
MF Hivert, AK Manning, JB McAteer, JC Florez… - Diabetes, 2008 - Am Diabetes Assoc
OBJECTIVE—Variants in ADIPOQ have been inconsistently associated with adiponectin
levels or diabetes. Using comprehensive linkage disequilibrium mapping, we genotyped …
levels or diabetes. Using comprehensive linkage disequilibrium mapping, we genotyped …
Genome‐wide linkage and association analyses to identify genes influencing adiponectin levels: the GEMS stud
H Ling, DM Waterworth, HA Stirnadel, TI Pollin… - …, 2009 - Wiley Online Library
Adiponectin has a variety of metabolic effects on obesity, insulin sensitivity, and
atherosclerosis. To identify genes influencing variation in plasma adiponectin levels, we …
atherosclerosis. To identify genes influencing variation in plasma adiponectin levels, we …
[HTML][HTML] Exome-derived adiponectin-associated variants implicate obesity and lipid biology
Circulating levels of adiponectin, an adipocyte-secreted protein associated with
cardiovascular and metabolic risk, are highly heritable. To gain insights into the biology that …
cardiovascular and metabolic risk, are highly heritable. To gain insights into the biology that …
[HTML][HTML] Adiponectin concentrations: a genome-wide association study
Adiponectin is associated with obesity and insulin resistance. To date, there has been no
genome-wide association study (GWAS) of adiponectin levels in Asians. Here we present a …
genome-wide association study (GWAS) of adiponectin levels in Asians. Here we present a …
Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals
OBJECTIVE: Plasma adiponectin is strongly associated with various components of
metabolic syndrome, type 2 diabetes and cardiovascular outcomes. Concentrations are …
metabolic syndrome, type 2 diabetes and cardiovascular outcomes. Concentrations are …
Genetics of adiponectin
J Breitfeld, M Stumvoll, P Kovacs - Biochimie, 2012 - Elsevier
Anti-inflammatory, anti-atherogenic and anti-diabetic properties of adiponectin make this
adipokine an attractive target in the metabolism research. Given its biological role, genetic …
adipokine an attractive target in the metabolism research. Given its biological role, genetic …
[HTML][HTML] A cross-ancestry genome-wide meta-analysis, fine-mapping, and gene prioritization approach to characterize the genetic architecture of adiponectin
V Sarsani, SM Brotman, Y Xianyong, LF Silva… - Human Genetics and …, 2024 - cell.com
Previous genome-wide association studies (GWASs) for adiponectin, a complex trait linked
to type 2 diabetes and obesity, identified> 20 associated loci. However, most loci were …
to type 2 diabetes and obesity, identified> 20 associated loci. However, most loci were …
A Genome-Wide Association Study Reveals a Quantitative Trait Locus of Adiponectin on CDH13 That Predicts Cardiometabolic Outcomes
OBJECTIVE The plasma adiponectin level, a potential upstream and internal facet of
metabolic and cardiovascular diseases, has a reasonably high heritability. Whether other …
metabolic and cardiovascular diseases, has a reasonably high heritability. Whether other …
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