Selective STING stimulation in dendritic cells primes antitumor T cell responses
B Jneid, A Bochnakian, C Hoffmann, F Delisle… - Science …, 2023 - science.org
T cells that recognize tumor antigens are crucial for mounting antitumor immune responses.
Induction of antitumor T cells in immunogenic tumors depends on STING, the intracellular …
Induction of antitumor T cells in immunogenic tumors depends on STING, the intracellular …
STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade
J Fu, DB Kanne, M Leong, LH Glickman… - Science translational …, 2015 - science.org
Stimulator of interferon genes (STING) is a cytosolic receptor that senses both exogenous
and endogenous cytosolic cyclic dinucleotides (CDNs), activating TBK1/IRF3 (interferon …
and endogenous cytosolic cyclic dinucleotides (CDNs), activating TBK1/IRF3 (interferon …
[HTML][HTML] CD4 T cell-intrinsic STING signaling controls the differentiation and effector functions of TH1 and TH9 cells
I Benoit-Lizon, E Jacquin, TR Vargas… - … for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background While stimulator of interferon genes (STING) activation in innate immune cells
of the tumor microenvironment can result in CD8 T cell-dependent antitumor immunity …
of the tumor microenvironment can result in CD8 T cell-dependent antitumor immunity …
TNFα and radioresistant stromal cells are essential for therapeutic efficacy of cyclic dinucleotide STING agonists in nonimmunogenic tumors
BJ Francica, A Ghasemzadeh, AL Desbien… - Cancer immunology …, 2018 - AACR
Abstract The cGAS–STING cytosolic DNA sensing pathway may play an integral role in the
initiation of antitumor immune responses. Studies evaluating the immunogenicity of various …
initiation of antitumor immune responses. Studies evaluating the immunogenicity of various …
[PDF][PDF] Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity
L Corrales, LH Glickman, SM McWhirter, DB Kanne… - Cell reports, 2015 - cell.com
Spontaneous tumor-initiated T cell priming is dependent on IFN-β production by tumor-
resident dendritic cells. On the basis of recent observations indicating that IFN-β expression …
resident dendritic cells. On the basis of recent observations indicating that IFN-β expression …
[PDF][PDF] Extrinsic phagocyte-dependent STING signaling dictates the immunogenicity of dying cells
J Ahn, T Xia, AR Capote, D Betancourt, GN Barber - Cancer cell, 2018 - cell.com
The ability of dying cells to activate antigen-presenting cells (APCs) is carefully controlled to
avoid unwarranted inflammatory responses. Here, we show that engulfed cells containing …
avoid unwarranted inflammatory responses. Here, we show that engulfed cells containing …
NK cells mediate clearance of CD8+ T cell–resistant tumors in response to STING agonists
CJ Nicolai, N Wolf, IC Chang, G Kirn, A Marcus… - Science …, 2020 - science.org
Several immunotherapy approaches that mobilize CD8+ T cell responses stimulate tumor
rejection, and some, such as checkpoint blockade, have been approved for several cancer …
rejection, and some, such as checkpoint blockade, have been approved for several cancer …
Intratumoral administration of cGAMP transiently accumulates potent macrophages for anti-tumor immunity at a mouse tumor site
T Ohkuri, A Kosaka, K Ishibashi, T Kumai… - Cancer Immunology …, 2017 - Springer
Stimulator of IFN genes (STING) spontaneously contributes to anti-tumor immunity by
inducing type I interferons (IFNs) following sensing of tumor-derived genomic DNAs in the …
inducing type I interferons (IFNs) following sensing of tumor-derived genomic DNAs in the …
[PDF][PDF] Magnitude of therapeutic STING activation determines CD8+ T cell-mediated anti-tumor immunity
KE Sivick, AL Desbien, LH Glickman, GL Reiner… - Cell reports, 2018 - cell.com
Intratumoral (IT) STING activation results in tumor regression in preclinical models, yet
factors dictating the balance between innate and adaptive anti-tumor immunity are unclear …
factors dictating the balance between innate and adaptive anti-tumor immunity are unclear …
Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy
Cyclic dinucleotide (CDN) agonists of stimulator of interferon genes (STING) are a promising
class of immunotherapeutics that activate innate immunity to increase tumour …
class of immunotherapeutics that activate innate immunity to increase tumour …