Low dose ketamine reduces pain perception and blood pressure, but not muscle sympathetic nerve activity, responses during a cold pressor test
Key points Low dose ketamine is a leading medication used to provide analgesia in pre‐
hospital and hospital settings. Low dose ketamine is increasingly used off‐label to treat …
hospital and hospital settings. Low dose ketamine is increasingly used off‐label to treat …
Racemic ketamine decreases muscle sympathetic activity but maintains the neural response to hypotensive challenges in humans
P Kienbaum, T Heuter, MC Michel… - The Journal of the …, 2000 - pubs.asahq.org
Background Cardiovascular stimulation and increased catecholamine plasma
concentrations during ketamine anesthesia have been attributed to increased central …
concentrations during ketamine anesthesia have been attributed to increased central …
Low‐dose ketamine affects blood pressure, but not muscle sympathetic nerve activity, during progressive central hypovolemia without altering tolerance
Key points Haemorrhage is the leading cause of battlefield and civilian trauma deaths.
Given that a haemorrhagic injury on the battlefield is almost always associated with pain, it is …
Given that a haemorrhagic injury on the battlefield is almost always associated with pain, it is …
S (+)-ketamine effect on experimental pain and cardiac output: a population pharmacokinetic-pharmacodynamic modeling study in healthy volunteers
M Sigtermans, A Dahan, R Mooren… - The Journal of the …, 2009 - pubs.asahq.org
Background Low-dose ketamine behaves as an analgesic in the treatment of acute and
chronic pain. To further understand ketamine's therapeutic profile, the authors performed a …
chronic pain. To further understand ketamine's therapeutic profile, the authors performed a …
S (+)-Ketamine Increases Muscle Sympathetic Activity and Maintains the Neural Response to Hypotensive Challenges in Humans
P Kienbaum, T Heuter, G Pavlakovic… - The Journal of the …, 2001 - pubs.asahq.org
Background S (+)-Ketamine is reported to exert twofold greater analgesic and hypnotic
effects but a shorter recovery time in comparison with racemic ketamine, indicating possible …
effects but a shorter recovery time in comparison with racemic ketamine, indicating possible …
The dose-dependent effect of S (+)-ketamine on cardiac output in healthy volunteers and complex regional pain syndrome type 1 chronic pain patients
E Olofsen, M Sigtermans, I Noppers… - Anesthesia & …, 2012 - journals.lww.com
BACKGROUND: Ketamine is used as an analgesic for treatment of acute and chronic pain.
While ketamine has a stimulatory effect on the cardiovascular system, little is known about …
While ketamine has a stimulatory effect on the cardiovascular system, little is known about …
An update on the basic and clinical science of ketamine analgesia
LV Doan, J Wang - The Clinical journal of pain, 2018 - journals.lww.com
Objective: In the context of the current opioid epidemic, there has been a renewed interest in
the use of ketamine as an analgesic agent. Methods: We reviewed ketamine analgesia …
the use of ketamine as an analgesic agent. Methods: We reviewed ketamine analgesia …
Factors influencing the cardiovascular response to subanesthetic ketamine: a randomized, placebo-controlled trial
Background The increasing use of ketamine as a potential rapid-onset antidepressant
necessitates a better understanding of its effects on blood pressure and heart rate, well …
necessitates a better understanding of its effects on blood pressure and heart rate, well …
Cognitive impairment after small-dose ketamine isomers in comparison to equianalgesic racemic ketamine in human volunteers
EG Pfenninger, ME Durieux… - The Journal of the …, 2002 - pubs.asahq.org
Background Ketamine is increasingly used in pain therapy but may impair brain functions.
Mood and cognitive capacities were compared after equianalgesic small-dose S (+)-, R (-) …
Mood and cognitive capacities were compared after equianalgesic small-dose S (+)-, R (-) …
Assessment of low-dose iv ketamine infusions for adjunctive analgesia
Purpose The results of a study evaluating all patients treated with adjunctive low-dose
ketamine for analgesia over a three-year period are presented. Methods A retrospective …
ketamine for analgesia over a three-year period are presented. Methods A retrospective …