Background: Oral commensals contribute to microbe-host symbiosis in periodontal
homeostasis, and Porphyromonas gingivalis (P. gingivalis) as the keystone pathogen …

Objective Porphyromonas gingivalis is involved in the pathogenesis of chronic inflammatory
periodontal disease. Recent studies have suggested that the NLRP3 inflammasome plays …

Porphyromonas gingivalis is a Gram‐negative anaerobic bacterium that has been
considered to be one of the bacteria associated with progression of human periodontitis …

Porphyromonas gingivalis, a major periodontopathogen, is involved in the pathogenesis of
periodontitis. Interleukin-1β (IL-1β), a proinflammatory cytokine, regulates innate immune …

Background Gingival epithelial cells are the major population of the gingival tissue, acting as
the front-line defense against microbial intrusion and regulating the homeostasis of the …

The interleukin (IL)-1β-processing inflammasome has recently been identified as a target for
pathogenic evasion of the inflammatory response by a number of bacteria and viruses. We …

Inflammasomes are large multiprotein complexes localized in the cytoplasm of the cell. They
are responsible for the maturation of pro-inflammatory cytokines such as interleukin-1β (IL …

Recognition of pathogen-associated molecular patterns that activate IL-1β is regulated by
inflammasomes, predominantly of the nucleotide-binding oligomerization domain-like …

Porphyromonas gingivalis has been shown to accelerate atherosclerotic lesion
development in hyperlipidemic animals. Atherosclerosis is a disease characterized by …

Inflammasomes serve as an intracellular machinery to initiate inflammatory response to
various danger signals. However, the chronic periodontitis pathological relevance of this …