Pain perception serves to protect living organism against an actual or potential tissue
damage. Glutamatergic signaling of nervous system plays a crucial role in initiating and …

Glutamate plays a key role in modulation of nociceptive processing. This excitatory amino
acid exerts its action through two distinct types of receptors, ionotropic and metabotropic …

The present study is to investigate if group III mGluRs are involved in peripheral nociception
by observing both nociceptive behavioral responses and Fos expression in spinal cord …

New findings• What is the topic of this review? This paper presents a review of the literature
of glutamate receptors and transporters in neuropathic pain and the role of glia in these …

Peripheral group III metabotropic glutamate receptors (mGluRs) function to modulate pain
signaling in inflammatory states. Here, we established in vivo experimental settings …

Increased glutamatergic input to spinal dorsal horn neurons constitutes an important
mechanism for neuropathic pain. However, the role of group III metabotropic glutamate …

The relatively new family of G-protein-coupled metabotropic glutamate receptors (mGluRs)
is comprised of eight cloned subtypes, which are classified into three groups based on their …

Highlights•Pain is one of the most common symptoms in clinical medicine.•Glutamate is the
main neurotransmitter involved in pain transmission.•Metabotropic glutamate receptors …

Metabotropic glutamate receptors (mGluRs) and their role in modulating pain throughout the
peripheral and central nervous system are the focus of this chapter. Because these …

Chronic neuropathic pain remains an unmet clinical problem because it is often resistant to
conventional analgesics. Metabotropic glutamate receptors (mGluRs) are involved in …