Neoadjuvant sintilimab and chemotherapy for resectable esophageal squamous cell carcinoma: a prospective, single-arm, phase II study

G Jincheng - 2023 - researchsquare.com
Background: Combining PD-1 blockade with chemotherapy has widely used in first line
treatment of metastatic esophageal squamous cell carcinoma (ESCC). However, their …

Neoadjuvant sintilimab combined with chemotherapy in patients with resectable esophageal squamous cell carcinoma (ESCC): Preliminary results from a phase II …

J Guo, C Qiao, J Lu, S Yang, B Zhang - 2022 - ascopubs.org
e16008 Background: Although preoperative chemoradiotherapy is the standard of care for
patients with resectable locally advanced esophageal cancer, prognosis still remains poor …

Neoadjuvant sintilimab and chemotherapy in patients with resectable esophageal squamous cell carcinoma: a prospective, single-arm, phase 2 trial

Z Zhang, J Ye, H Li, D Gu, M Du, D Ai, W Chen… - Frontiers in …, 2022 - frontiersin.org
Background Immunotherapy (Programmed cell death 1 blockade) has entered the ranks of
advanced esophageal cancer first-line treatment; however, little is known about the efficacy …

110P Neoadjuvant PD-1 blockade combined with chemotherapy for patients with resectable locally advanced esophageal squamous cell carcinoma (ESCC): A real …

H Lv, Y Tian, C Huang, B Sun, C Gai, Z Li… - Annals of …, 2021 - annalsofoncology.org
Background Compared with neoadjuvant chemotherapy, concurrent radiotherapy can
significantly increase pCR rate and improve overall survival of Locally Advanced ESCC …

1378P a single-center, prospective, open-label, single-arm trial of sintilimab with paclitaxel and carboplatin as a neoadjuvant therapy for esophageal squamous …

Z Zhang, J Ye, H Li, M Du, D Gu, J Zhang… - Annals of …, 2021 - annalsofoncology.org
Background Although neoadjuvant chemotherapy has been recommended for resectable
ESCC patients, the 5-year overall survival rate was less than 50%. Immune checkpoint …

The survival outcomes of neoadjuvant sintilimab combined with chemotherapy in patients with locally advanced esophageal squamous cell carcinoma

H Lv, C Huang, J Li, F Zhang, C Gai, Z Liu… - Frontiers in …, 2023 - frontiersin.org
Background Neoadjuvant programmed death receptor-1 (PD-1) inhibitor combined with
chemotherapy has been reported to improve the pathological response of locally advanced …

[HTML][HTML] Neoadjuvant sintilimab and chemotherapy in patients with potentially resectable esophageal squamous cell carcinoma (KEEP-G 03): an open-label, single …

X Chen, X Xu, D Wang, J Liu, J Sun, M Lu… - … for ImmunoTherapy of …, 2023 - ncbi.nlm.nih.gov
Background The standard neoadjuvant treatments in patients with esophageal squamous
cell carcinoma (ESCC) still have either poor safety or efficacy. Better therapies are needed …

175P A study of neoadjuvant sintilimab combined with triplet chemotherapy of lipo-paclitaxel, cisplatin, and S-1 for resectable esophageal squamous cell carcinoma …

Y Gu, X Chen, D Wang, M Ding, L Xue… - Annals of …, 2020 - annalsofoncology.org
Background Although preoperative chemoradiotherapy is the standard of care for patients
(pts) with resectable locally advanced esophageal cancer, ESCC still has a dismal …

The efficacy and safety of neoadjuvant sintilimab combined with chemotherapy in resectable locally advanced lymph node-positive esophageal squamous cell …

P Ye, A Rusidanmu, S Lin, K Zhou, X Wu, B Huang… - 2024 - ascopubs.org
e16091 Background: Many phase III clinical trials (Keynote 590, Orient 15, etc) have all
proved the role of immunotherapy combined with chemotherapy in the treatment of …

[HTML][HTML] Neoadjuvant sintilimab plus chemotherapy for locally advanced esophageal squamous cell carcinoma: a single-arm, single-center, phase 2 trial (ESONICT-1)

Z Zhang, ZN Hong, S Xie, W Lin, Y Lin… - Annals of …, 2021 - ncbi.nlm.nih.gov
Background To investigate the safety and feasibility of combining neoadjuvant sintilimab
(Innovent Biologics, Suzhou, China) and chemotherapy for locally advanced esophageal …