Cytotoxic CD8+ T cells play a key role in the elimination of intracellular infections and
malignant cells and can provide long-term protective immunity. In the response to infection …

CD8+ T cells are central players in controlling infections and cancer. Longevity, functionality,
and metabolic fitness are critical determinants of T cell efficacy in cancer immunotherapy …

In healthy individuals, metabolically quiescent T cells survey lymph nodes and peripheral
tissues in search of cognate antigens. During infection, T cells that encounter cognate …

In the past several years a wealth of evidence has emerged illustrating how metabolism
supports many aspects of T cell biology, as well as how metabolic changes drive T cell …

T lymphocytes are a critical component of the adaptive immune system mediating protection
against infection and malignancy, but also implicated in many immune pathologies. Upon …

T cells have a pivotal protective role in defense against infection and cancer but also are
instrumental in the development of many autoimmune diseases. The regulation of nutrient …

T cell metabolism has a central role in supporting and shaping immune responses and may
have a key role in antitumor immunity. T cell metabolism is normally held under tight …

This Review explores the interplay between T cell activation and cell metabolism and
highlights how metabolites serve two pivotal functions in shaping the immune response …

In the past years, there have been significant advances in the understanding of how
environmental conditions alone or in conjunction with pathogen invasion affect the …

Metabolism drives function, on both an organismal and a cellular level. In T cell biology,
metabolic remodeling is intrinsically linked to cellular development, activation, function …