Precision medicine gives individuals tailored medical treatment, with the genotype
determining the therapeutic strategy, the appropriate dosage, and the likelihood of benefit or …

Introduction: Africa harbors a disproportionate burden of disease when taking into account
the triple challenge caused by HIV/AIDS, tuberculosis (TB) and malaria, against a backdrop …

The health burden resulting from parasitic and infectious diseases such as HIV/AIDS,
tuberculosis and malaria, requires that available medication and limited healthcare …

Abstract The Cytochrome P450 (CYP450) family of enzymes is involved in the oxidative
metabolism of many therapeutic drugs, carcinogens and various endogenous substrates …

T hough the pharmacogenetics of drug metabolism had its origins in the 1960s, it is only
during the past 10 years that it began to have clinical impact and pharmaceutical industry …

Background: The cytochrome P450 enzymes (CYP) play an important role in the metabolism
of many therapeutic agents. The activities of different enzymes exhibit variability in different …

The genomics revolution has provided a plethora of data from many previously
uncharacterized populations. The increase in the amount of genetic data has improved our …

Abstract Background The cytochrome P450 CYP2B6* 6 (CYP2B6 c. 516G> T; rs3745274) is
one of the genetic factors that alters the drug metabolism in antimalarial, antiretroviral and …

(PCR/RFLP) and DNA sequencing techniques. The frequencies of the CYP2B6* 6 poor
metabolizer (PM) genotype (15631G> T (Q172H) and/or 18053A> G (K262R) were not …

Aim The aim of this study was to obtain pharmacogenetic data in a Vietnamese population
on genes coding for proteins involved in the elimination of drugs currently used for the …