Purinergic signaling was proposed in 1972, after it was demonstrated that adenosine 5′-
triphosphate (ATP) was a transmitter in nonadrenergic, noncholinergic inhibitory nerves …

A brief account of the early history of extracellular signalling by ATP will be followed by a
summary of the current subclassification of receptors for purines and pyrimidines. On the …

Abstract Adenosine 5′‐triphosphate (ATP) was identified in 1970 as the transmitter
responsible for non‐adrenergic, non‐cholinergic neurotransmission in the gut and bladder …

[Frontiers in Bioscience E3, 896-900, June 1, 2011] 896 Introductory overview of purinergic
signalling Geoffrey Burnstock1 1Aut Page 1 [Frontiers in Bioscience E3, 896-900, June 1, 2011] …

In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists
were sceptical about its validity, largely because ATP was so well established as an …

Purinergic signalling, ie ATP as an extracellular signalling molecule and cotransmitter in
both peripheral and central neurons, is involved in the physiology of neurotransmission and …

This review is focused on purinergic neurotransmission, ie, ATP released from nerves as a
transmitter or cotransmitter to act as an extracellular signaling molecule on both pre-and …

While there were early papers about the extracellular actions of purines, the role of ATP as a
purinergic neurotransmitter in nonadrenergic, noncholinergic nerves in the gut and bladder …

Purinergic neurotransmission, involving release of ATP as an efferent neurotransmitter was
first proposed in 1972. Later, ATP was recognised as a cotransmitter in peripheral nerves …

Physiological evidence supporting the role of the adenine nucleotide, ATP 1 (Figure 1), as a
neurotransmitter was first summarized in detail in 1972, 1 representing the basis of …