… The liver is the most affected organ, since ethanol is mostly metabolized there [11,13], but
gastrointestinal, central, and peripheral nervous systems; the heart and vascular system; …

… inflammatory and pro-fibrogenic responses, increasing the risk of liver cancer [44]. Because
there … ethanol metabolism, this section reviews the mechanisms underlying oxidative ethanol …

… ethanol metabolism via increased ethanol metabolizing expression and activity. The
enhancement of this metabolic … (NAD), a cofactor required for ethanol metabolism. Additionally, the …

… With slower ethanol metabolism, more ethanol is able to reach the brain and elicit hangover
… , assessment of biomarkers of alcohol metabolism suggests that fast elimination of ethanol is …

… Ethanol is oxidized into acetaldehyde by alcohol … Another major pathway of ethanol
metabolism includes its oxidation in … In parallel, ROS are formed through the metabolism of …

… In this study, a rat model of chronic heavy ethanol consumption was used to investigate
the relevance of ethanol-induced GM dysbiosis to the metabolic phenotype alterations in the …

… metabolism per se that is required for hepatic lipid dysregulation. Once metabolized, alcohol
… In this review, we focus predominantly on alcohol's dysregulation of triglyceride metabolism, …

… For patients with a BMI <25 kg/m 2 at least 2 metabolic risk abnormalities need to be present
in addition to hepatic steatosis. Of note, MAFLD criteria have been applied regardless of …

… to PHHs for preclinical drug metabolism and hepatotoxicity assessments. Altogether, HepaRG
… showed lower albumin secretion and enzyme activity in the ethanol-treated group than in …

… consumes 1 alcoholic drink daily (10 g ethanol) risk is similar to that of a man with a low
WHR (green) who consumes 4 alcoholic drinks daily (40 g ethanol). Results are based on Cox …