… mTOR inhibition in HCC which, through SHP2, leads to reactivation of the mTOR pathway. …
We show here that a combination of mTOR and SHP2 inhibitors is highly synergistic in …

… pathway inhibition by SHP2 inhibitors may promote the open conformation of SHP2 and
lead to resistance to SHP2 inhibitors. … this RAS reactivation following initial SHP2 inhibition is …

… by reactivation of RAS-MEK-ERK and AKT pathways. Combined use of SHP2 inhibitor (10)
with sorafenib can block the reactivation of MEK/ERK and AKT signaling pathways, thus …

… reactivated ERK upon treatment for 12 h in A549 cells, and SHP2 inhibition by JC-010a
prevented the reactivation of … can inhibit the reactivated RTK/SHP2/MAPK signaling pathway to …

… of MEK induces negative feedback to increase the RTK activity that leads to the reactivation
of RAS/Raf/ERK pathway or increases the activities of other cascades, such as PI3K/AKT …

… associated with drug resistance (Datta et al., 2017; Song et al., 2017; Vitiello et al., 2019),
we propose that the blockage of the reactivation of the AKT pathway in response to SHP2 …

… Thus, our results suggest that SHP2 inhibition can mitigate … feedback reactivation of RAS
and MAPK pathway signaling in … SHP2 inhibition can abrogate adaptive feedback reactivation …

… that blocking SHP2 reverses the reactivation of the MAPK/ERK signaling pathway caused
by the … of the overlap of SHP2 and RTKs signaling pathways, SHP2 inhibitors can be used in …

… data as to whether PTPN11 mutational status determines SHP2 inhibitor sensitivity in non-neuroblastoma
cells, we assessed the efficacy of SHP2 inhibitors in isogenic SH-EP and Kelly …

… of SHP2 in RAS-driven cancers and the therapeutic potential of allosteric SHP2 inhibitors as
… Reactivation of RAS pathway signaling may underlie the lack of therapeutic efficacy, as with …