Overview of nanoparticulate strategies for solubility enhancement of poorly soluble drugs

KU Khan, MU Minhas, SF Badshah, M Suhail, A Ahmad… - Life Sciences, 2022 - Elsevier
… Nanogels have greater potential as novel, safe, and effective carrier system for solubility
enhancement of poor soluble drugs due to smaller size, large surface area, high drug loading …

[HTML][HTML] A review on solid dispersion and carriers used therein for solubility enhancement of poorly water soluble drugs

AR Tekade, JN Yadav - Advanced pharmaceutical bulletin, 2020 - ncbi.nlm.nih.gov
… One of the successful approaches for enhancement of solubility of poorly soluble drug is
conversion of crystalline form of drug to an amorphous from. For successful solid dispersion …

[HTML][HTML] Bioavailability enhancement techniques for poorly aqueous soluble drugs and therapeutics

DV Bhalani, B Nutan, A Kumar, AK Singh Chandel - Biomedicines, 2022 - mdpi.com
… Class II and IV drugs (APIs) exhibit poor solubility, lower bioavailability, and less dissolution.
… in this article to improve the solubility of poorly water-soluble drugs, for example, the …

Solubility enhancement and application of cyclodextrins in local drug delivery

DH Kim, SE Lee, YC Pyo, P Tran, JS Park - Journal of Pharmaceutical …, 2020 - Springer
… CDs can improve biopharmaceutical performance by increasing the apparent solubility and
dissolution rate of poorly water-soluble drugs. Typical complex formation mechanisms and …

Nanonization techniques to overcome poor water-solubility with drugs

FLO Da Silva, MBDF Marques, KC Kato… - Expert opinion on drug …, 2020 - Taylor & Francis
poor water-solubility and the main strategies applied to increase the solubility of poorly
water-soluble drugs. … solubilization process of the drug is also considered. Finally, it includes how …

Eutectic mixtures as an approach to enhance solubility, dissolution rate and oral bioavailability of poorly water-soluble drugs

GC Bazzo, BR Pezzini, HK Stulzer - International Journal of Pharmaceutics, 2020 - Elsevier
… the solubility and dissolution of poorly water-soluble drugs … the solubility and oral bioavailability
of poorly soluble drugs has increased considerably, including drug-carrier and drug-drug

Co-amorphous systems for the delivery of poorly water-soluble drugs: Recent advances and an update

J Han, Y Wei, Y Lu, R Wang, J Zhang… - Expert opinion on drug …, 2020 - Taylor & Francis
… apparent solubility and dissolution behavior of insoluble APIs… drug combinations are also
intended to form CAM in order to not only enhance solubility/dissolution of poorly soluble drugs

In vitro and in vivo evaluation of porous lactose/mannitol carriers for solubility enhancement of poorly water-soluble drugs

N Jiang, S Wang, Z Cheng, W Liu - Drying technology, 2020 - Taylor & Francis
… as drug carriers represents a new solubility enhancement strategy for poorly soluble drugs.
In … drying and template removal method with Indomethacin loaded as a model drug. In vitro …

[PDF][PDF] … : Potential of solid dispersions to enhance solubility, bioavailability, and therapeutic efficacy of poorly water-soluble drugs: newer formulation techniques, current …

S Alshehri, SS Imam, A Hussain, MA Altamimi… - Drug …, 2020 - Taylor & Francis
… Nowadays, there are number of marketed SDs have firmly established using different
techniques for the formulation of poorly soluble drugs (Table 1). The main reason for the limited …

[HTML][HTML] Improved release of a drug with poor water solubility by using electrospun water-soluble polymers as carriers

M Józó, N Simon, L Yi, J Móczó, B Pukánszky - Pharmaceutics, 2021 - mdpi.com
… for the slight decrease of equilibrium solubility. The improvement of solubility of the drug
as a result of its incorporation into polymer matrices is demonstrated well by Figure 10. The …