Role of mitochondrial therapy for ischemic-reperfusion injury and acute kidney injury

N Pabla, A Bajwa - Nephron, 2022 - karger.com
… Mitochondrial injury which causes ATP depletion and triggers apoptosis and necrosis … injury
(IRI). Pharmacological (SS-31 or MitoQ), cellular (dendritic cells or mesenchymal stem cells), …

[HTML][HTML] Reproducible large-scale isolation of exosomes from adipose tissue-derived mesenchymal stem/stromal cells and their application in acute kidney injury

JH Lee, DH Ha, H Go, J Youn, H Kim, RC Jin… - International Journal of …, 2020 - mdpi.com
… the paracrine effects of stem-cell therapy [10,11]. Interestingly, most of the animal studies
into the therapeutic effects of MSC-exosomes in kidney injuries have been performed with …

[HTML][HTML] Reno-protection of urine-derived stem cells in a chronic kidney disease rat model induced by renal ischemia and nephrotoxicity

C Zhang, SK George, R Wu, PU Thakker… - … Journal of Biological …, 2020 - ncbi.nlm.nih.gov
… Drug-induced nephrotoxicity occurs more frequently in patients with pre-existing renal
dysfunction or ischemia due to acute kidney injury, chronic kidney disorder, diabetic nephropathy, …

In Vivo Tracking of Mesenchymal Stem Cell-Derived Extracellular Vesicles Improving Mitochondrial Function in Renal Ischemia–Reperfusion Injury

H Cao, Y Cheng, H Gao, J Zhuang, W Zhang, Q Bian… - ACS …, 2020 - ACS Publications
… Extracellular vesicles (EVs) released by mesenchymal stem cells (MSCs) have exhibited
regenerative capability in animal models of ischemia–reperfusion (I/R) acute kidney injury (AKI) …

[HTML][HTML] Extracellular vesicles and acute kidney injury: potential therapeutic avenue for renal repair and regeneration

M Kosanović, B Milutinovic, S Glamočlija… - International journal of …, 2022 - mdpi.com
… Hence, EVs secreted by mesenchymal stem cells have arisen as a powerful cell-free … cells
and, consequently, the outcome of kidney injury. Whenever possible, we describe the cellular

Single-nuclear transcriptomics reveals diversity of proximal tubule cell states in a dynamic response to acute kidney injury

LMS Gerhardt, J Liu, K Koppitch… - Proceedings of the …, 2021 - National Acad Sciences
… 2 /M cell cycle arrest, distinct from other reports of maladaptive PTCs following kidney injury
Fate-mapping experiments identified spatially and temporally distinct origins for these cells. …

Recent updates on mesenchymal stem cell based therapy for acute renal failure

A Missoum - Current urology, 2020 - karger.com
… Du T, Zhu YJ: The regulation of inflammatory mediators in acute kidney injury via exogenous
mesenchymal stem cells. Mediators Inflamm 2014;2014:261697. Makris K, Spanou L: Acute …

[HTML][HTML] Human urine-derived stem cells protect against renal ischemia/reperfusion injury in a rat model via exosomal miR-146a-5p which targets IRAK1

X Li, J Liao, X Su, W Li, Z Bi, J Wang, Q Su, H Huang… - Theranostics, 2020 - ncbi.nlm.nih.gov
… Rationale: Ischemia/reperfusion injury (IRI) is a major cause of acute kidney injury (… stem
cells (USCs) and their exosomes against IRI-induced AKI to explore the potential of these cells

[PDF][PDF] Stem cell therapy in acute kidney Injury

GM Zou - American Journal of Translational …, 2023 - journals3.publicknowledgeproject …
… Mesenchymal stem cells (MSCs) are being considered as a promising alternative treatment
option for acute kidney injury (AKI) and other renal diseases. However, their use is limited …

Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury

Y Kirita, H Wu, K Uchimura… - Proceedings of the …, 2020 - National Acad Sciences
… Single nucleus RNA sequencing revealed gene expression changes during repair after acute
kidney injury. We describe a small population of proximal tubule cells that fail to repair (FR-…