… Targeted Protein Degradation (TPD) strategies have also been explored to target previously
undruggable proteins… of the proteins targeted by PROTACs and the biological effects of their …

… expanding the range of substrates. In this review, we first provide a simple introduction of
protein degradation … , will not only provide powerful tools for biomedical research, but hold great …

… be hijacked for targeted protein degradation—is still … protein degradation and approaches
used to identify or design E3 ligands, and highlight challenges and opportunities for targeting …

Of late, targeted protein degradation (TPD) has surfaced as a novel and innovative chemical
tool and therapeutic modality. By co-opting protein degradation pathways, TPD facilitates …

… biology tools as well as therapeutic approaches inducing targeted protein degradation and
… and proteolysis targeting chimeras (PROTACs) paving the way to expand the druggable …

… of the target protein. The broad … that target oncoproteins with tissue, tumour and subcellular
selectivity. In this Review, we first discuss the molecular basis of targeted protein degradation…

… To expand the reach of TPD to degrade other “hard to drug” … synthesis, and molecular
biology, tools now exist to identify ligands for almost any protein. This is underscored by the recent …

… the degradation of BRD4 and BCR-ABL, respectively. Our study showcases a covalent ligand
that targets … in expanding the arsenal of E3 ligase recruiters suitable for TPD applications. …

… In this current work, we extend upon our initial publication (41… Using these two new methods,
we then extend the test set … Figure 4 do suggest that the modeling tools of this work can …

… future to achieve the desired degradation results. In this paper, … degradation strategies for
different target proteins (Table 1). … PROTACs can extend the "target space" to the PPI target. It …