Drug delivery to macrophages: a review of targeting drugs and drug carriers to macrophages for inflammatory diseases

W He, N Kapate, CW Shields IV, S Mitragotri - Advanced drug delivery …, 2020 - Elsevier
inflammatory diseases, summarize the leading drugs used to regulate macrophages, and
review drug delivery systems designed to target … macrophage-targeted drug delivery systems. …

The cGAS–STING pathway as a therapeutic target in inflammatory diseases

A Decout, JD Katz, S Venkatraman… - Nature Reviews …, 2021 - nature.com
… , we examine pharmacological intervention strategies that target this pathway and discuss
their therapeutic potential in the treatment of inflammatory and autoinflammatory diseases. …

Mechanisms and therapeutic regulation of pyroptosis in inflammatory diseases and cancer

Z Zheng, G Li - International journal of molecular sciences, 2020 - mdpi.com
… of pyroptosis as a therapeutic target in human diseases. Blockade of pyroptosis by compounds
can treat inflammatory disease and pyroptosis activation contributes to cancer therapy. …

[HTML][HTML] NLRP3 inflammasome and inflammatory diseases

Z Wang, S Zhang, Y Xiao, W Zhang, S Wu… - … medicine and cellular …, 2020 - hindawi.com
… plays a vital role in regulating inflammation. In this review, NLRP3 … in inflammatory diseases,
interactions with autophagy, and targeted therapeutic approaches in inflammatory diseases

[HTML][HTML] A pH/ROS dual-responsive and targeting nanotherapy for vascular inflammatory diseases

R Zhang, R Liu, C Liu, L Pan, Y Qi, J Cheng, J Guo… - Biomaterials, 2020 - Elsevier
… (B) Engineering of a dual-responsive, targeting rapamycin nanotherapy based on a pH-…
material (OCD) as well as targeted treatment of a vascular inflammatory disease of restenosis. …

Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles

RQ Yao, C Ren, ZF Xia, YM Yao - Autophagy, 2021 - Taylor & Francis
… range of diseases, varying from inflammatory disease to … as well as the development of
various diseases ( Table 2 ). It is … will be a potential therapeutic target for maintaining cell viability …

Targeting cancer-promoting inflammation—have anti-inflammatory therapies come of age?

J Hou, M Karin, B Sun - Nature reviews Clinical oncology, 2021 - nature.com
… Thus, the use of anti-inflammatory agents, either alone or in combination with cytotoxic
agents and targeted therapies, is an appealing strategy for the treatment of inflammation-driven …

Inflammasomes as therapeutic targets in human diseases

Y Li, H Huang, B Liu, Y Zhang, X Pan, XY Yu… - … and targeted therapy, 2021 - nature.com
… In this review, we summarized the link between inflammasomes and sterile inflammatory
diseases, including CVDs, depression, neurodegenerative diseases, diabetes, and cancer. …

Janus kinase-targeting therapies in rheumatology: a mechanisms-based approach

Y Tanaka, Y Luo, JJ O'Shea… - Nature Reviews …, 2022 - nature.com
diseases (Table 1). In this Review we describe the progress in JAK-targeting therapies for
autoimmune rheumatic diseases, … of action, and discussion on a disease-by-disease basis. …

[HTML][HTML] … on viral replication and virus infection-induced inflammatory responses: a promising therapeutic target for virus infection-induced inflammatory diseases

X Ding, S Li, L Zhu - Cytokine & growth factor reviews, 2021 - Elsevier
… Application of HMGB1 inhibitors or neutralization antibody alleviates disease progression
in vivo HMGB1 is recognized as a therapeutic target for the treatment of inflammatory diseases