… In the present study, data showed that TGF-β might activate ERK, ADAM17, and RSK1
signaling pathways, which initiate C/EBPβ phosphorylation and the binding of C/EBPβ to the …

… inhibitor, PD98059, and JNK inhibitor, SP600125, were able to reverse TGF‑… TGF‑β1‑induced
autophagy is involved in the activation of JS1 cells, possibly through activation of the ERK …

… To further explore the mechanism of BTA-induced ERK activation, we used a selective
inhibitor of the ERK pathway. PD98059 was added to the HSF cells and incubated for 30 minutes …

… to the activation of the MAPK/ERK signaling pathway in HCC in autocrine and paracrine
manners. Epidermal growth factor (EGF) and transforming growth factor alpha (TGF-α) are the …

… angiogenesis-related signaling pathways, AKT, ERK, and TGF-β/… , partly by activating
AKT, ERK, and TGF-β/Smad3 signaling. … Thus, our data suggest that FASSs activate TGF-β/Smad3, …

… Recent observations revealed that IL-11, the crucial fibrosis gene acting downstream of
TGF-β1, also activated ERK in cardiac fibroblasts. Both TGFβ-1 and IL-11 require …

… of c-Raf, MEK (MAP kinase/ERK kinase) and ERK1/2 kinases (Figure 6A) [188]. Interestingly,
in human keratinocytes (HaCaT), it was demonstrated that ERK activation occurs when TGF…

… This study focused on the activation of the canonical TGF-β1/Smad2/3 and noncanonical …
We found that the activation of Erk 1/2 signaling by TGF-β1, in healthy SGEC treated with IL-17, …

… 2 can be activated by TGF-β1 in … activation of ERK is necessary for TGF-β1-induced fibroblast
replication (77). Notably, a complex cross-talk exists between TGF-β/Smad and TGF-β/ERK …

… that ERK-mediated Smad activation was blocked by ERK … activation was blocked by
U0126 also suggested ERK-… Our finding that abrogation of the TGF-β/Smad or ERK signaling …