The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies

N Zhao, B Di, L Xu - Cytokine & growth factor reviews, 2021 - Elsevier
NLRP3 inflammasome activation pathway. Second, we review the cellular/molecular
mechanisms of NLRP3 inflammasome … the involvement of the NLRP3 inflammasome in the …

[HTML][HTML] Targeting the NLRP3 inflammasome as a new therapeutic option for overcoming cancer

S Missiroli, M Perrone, C Boncompagni, C Borghi… - Cancers, 2021 - mdpi.com
… In this review, we will discuss the NLRP3 inflammasome as a … on current strategies for targeting
the NLRP3 inflammasome, … and that targeting NLRP3 is a promising therapeutic strategy. …

The NLRP3 inflammasome: Mechanism of action, role in disease and therapies

L Wang, AV Hauenstein - Molecular aspects of medicine, 2020 - Elsevier
… mechanisms of NLRP3 inflammasome activation, how dysregulation of NLRP3 inflammasome
activation causes disease, and potential therapeutics that inhibit NLRP3 inflammasome

Strategies for targeting the NLRP3 inflammasome in the clinical and preclinical space

AG Schwaid, KB Spencer - Journal of Medicinal Chemistry, 2020 - ACS Publications
… the excitement in the field for NLRP3 as a therapeutic target. As compounds progress, …
strategies have not been published, particularly considering the similar mode of action on NLRP3

The involvement of NLRP3 inflammasome in the treatment of Alzheimer's disease

YS Feng, ZX Tan, LY Wu, F Dong, F Zhang - Ageing research reviews, 2020 - Elsevier
… of the molecular mechanisms associated with the onset and progression of AD is critical to
provide a theoretical basis for the establishment of novel preventive and therapeutic strategies

[HTML][HTML] Therapeutic regulation of the NLRP3 inflammasome in chronic inflammatory diseases

JK Seok, HC Kang, YY Cho, HS Lee, JY Lee - Archives of Pharmacal …, 2021 - Springer
therapeutic applications targeting the NLRP3 inflammasome to … This review extensively
discusses NLRP3 inflammasome-… the design of therapeutic strategies for NLRP3 inflammasome-…

[HTML][HTML] … white matter injury mediated by neuroinflammation after intracerebral hemorrhage and promising therapeutic strategies of targeting the NLRP3 inflammasome

L Xiao, M Wang, Y Shi, Y Xu, Y Gao… - Current …, 2023 - ncbi.nlm.nih.gov
… Thus, this review summarized the important role of NLRP3 inflammasome in secondary WMI
and promising therapeutic strategies for targeting NLRP3 inflammasome for WMI after ICH (…

Therapeutic potential of the target on NLRP3 inflammasome in multiple sclerosis

S Shao, C Chen, G Shi, Y Zhou, Y Wei, N Fan… - … & therapeutics, 2021 - Elsevier
NLRP3 inflammasomeNLRP3 inflammasome activation plays a key role in the progression
of MS or EAE. Therefore, targeting the NLRP3 inflammasome might be a therapeutic strategy

Spotlight on NLRP3 inflammasome: role in pathogenesis and therapies of atherosclerosis

C Jiang, S Xie, G Yang, N Wang - Journal of Inflammation …, 2021 - Taylor & Francis
therapeutic strategies targeting NLRP3 inflammasome to … activation is vital in seeking reliable
and effective therapies against AS. … of NLRP3 inflammasome activation, the role of NLRP3

[HTML][HTML] The involvement of NLRP3 inflammasome in the treatment of neurodegenerative diseases

YS Feng, ZX Tan, LY Wu, F Dong, F Zhang - Biomedicine & …, 2021 - Elsevier
… the NLRP3 inflammasome pathway and alleviate neuroinflammation. Finally, we will summarize
the novel treatment strategiestherapeutic strategies for the treatment of these diseases. …