… used as oral anti-cancer drugs in combination with thymidine phosphorylase inhibitor in the
treatment of refractory colorectal cancer. [ Citation 26 ] Upon uptake into the cells TFT can be …

… Using a large-scale transcriptomic database and survival correlation screening, we identify
thymidine kinase 1 (TK1) as a key driver. The progression of HCC is robustly mitigated by …

… In this study, we evaluated the potential of nucleoside analogs and thymidine kinase-based
suicide genes. Among tested thymidine kinase variants, the humanized SR39 (SR39h) …

… of thymidine kinases from the TK1 family. A, alignment overview of TK1 family members
including thymidine kinases … performed with three of the thymidine kinases. The G. intestinalis …

… We here discuss cellular uptake and intracellular … in vitro thymidine kinase-mediated
phosphorylation of the anti-HIV agent zidovudine has been found to be blocked by thymidine [68]. …

… TS inhibition upregulates the thymidine salvage pathway including … uptake that subsequently
decreases with reduced proliferation. This study was conducted to assess FLT uptake as an …

… curve for calculating the copy number of TK–NTR and TK–p53–NTR plasmids delivered into
cells for the respective treatments in the cellular uptake studies and in vivo in living animals. …

BrdU (bromodeoxyuridine) and EdU (ethynyldeoxyuridine) have been largely utilized as the
means of monitoring DNA replication and cellular division. Although BrdU induces gene …

Thymidine kinase 1 (TK1) phosphorylates thymidine nucleosides to generate thymidine
monophosphate. This reaction belongs to the pyrimidine salvage route that is phylogenetically …

… , EdU requires cellular uptake via nucleoside transporters followed by stepwise phosphorylation
with thymidine kinase (TK), thymidylate kinase, and nucleoside diphosphate kinase to …