Hormonal regulation of autophagy in thyroid PCCL3 cells and the thyroids of male mice

T Kurashige, Y Nakajima, M Shimamura… - Journal of the …, 2020 - academic.oup.com
… rat normal thyroid cell line PCCl3 to study the regulation of autophagy in vitro. The cells were
… , respectively, of autophagic activity, indicating that PCCl3 cells have functional autophagy. …

Reevaluation of the Effect of Iodine on Thyroid Cell Survival and Function Using PCCL3 and Nthy-ori 3-1 Cells

T Kurashige, M Shimamura… - Journal of the Endocrine …, 2020 - academic.oup.com
… on thyroid cells, we have recently pointed out the critical differences between FRTL5/PCCL3
cells and Nthy-ori 3-1 cells. Therefore, we here directly compared some of the cellular

[PDF][PDF] Zinc Depletion Inhibits the Synthesis and Secretion of Thyroglobulin by Inducing Endoplasmic Reticulum Stress in PCCL3 Thyroid Cells

K Kwon, ER Lee, KH Kang, TS Hwang… - … Journal of Biology …, 2022 - npublications.com
… of Tpen concentrations and treatment times on PCCL3 thyroid cells’ viability. In most experiments,
… of Tg, the main precursor of thyroid hormones, in thyroid PCCL3 cells. As a result, the …

[HTML][HTML] TGF-β1 Disrupts redox balance in PCCL3 thyroid cell and is sexually dimorphic expressed in rat thyroid gland

CC de Faria, FHC Medeiros, JC Menezes… - Molecular and Cellular …, 2022 - Elsevier
… in the rat thyroid cell PCCL3 and the interrelationship between … thyroid glands of rats in
comparison to males. Moreover, 17β-estradiol treatment enhanced TGF-β1 mRNA in PCCL3 cells

Commentary: Excessive Iodine Promotes Pyroptosis of Thyroid Follicular Epithelial Cells in Hashimoto's Thyroiditis Through the ROS-NF-κB-NLRP3 Pathway

Y Nagayama - Frontiers in Endocrinology, 2020 - frontiersin.org
… immortalized cell lines and their growth is totally TSH-dependent, a characteristic of differentiated
thyroid cells, take up iodine. We recently confirmed that PCCL3 cells incorporated 131 …

[HTML][HTML] Investigating the mechanisms of action of thyroid disruptors: A multimodal approach that integrates in vitro and metabolomic analysis

NC Rolland, F Graslin, F Schorsch, T Pourcher… - Toxicology in Vitro, 2024 - Elsevier
… NIS activity was studied by measuring iodide uptake in PCCL3 cells. Rat follicular thyroid
PCCL3 cells were cultured in a 24-well plate with F12/Coon's 5% SVF medium (supplemented …

Crocin treatment promotes the oxidative stress and apoptosis in human thyroid cancer cells FTC‐133 through the inhibition of STAT/JAK signaling pathway

Y Zhang, M Zhu, S Krishna Mohan… - Journal of Biochemical …, 2021 - Wiley Online Library
… Crocin did not show toxicity to the normal thyroid (PCCL3) cells. Crocin-induced reactive
oxygen species, mitochondrial membrane potential activity, caspase-8 and -9, lipid …

TNFα-mediated activation of NF-κB downregulates sodium-iodide symporter expression in thyroid cells

M Faria, R Domingues, F Paixão, MJ Bugalho… - PLoS …, 2020 - journals.plos.org
PCCL3 cell line as an additional cellular model. This, like the FRTL5 cell line, is also a
non-neoplastic rat thyroid follicular cell… Serum-starved cells were subjected to TSH stimulation and …

Thyroid follicular cell loss of differentiation induced by microRNA miR-17-92 cluster is attenuated by CRISPR/Cas9n gene silencing in anaplastic thyroid cancer

CS Fuziwara, KC Saito, ET Kimura - Thyroid, 2020 - liebertpub.com
… biology, we overexpressed the miR-17-92 cluster in normal rat thyroid follicular cells
PCCl3 (stable cell line PCCl3-miR-17-92) (Fig. 4A). miR-17-92 overexpression increased …

GLIS3 regulates transcription of thyroid hormone biosynthetic genes in coordination with other thyroid transcription factors

HS Kang, SA Grimm, R Jothi, P Santisteban, AM Jetten - Cell & Bioscience, 2023 - Springer
… glands and the GLIS3-HA, NKX2.1, and FOXE1 ChIP-seq data from PCCl3 cells generated
in this study were deposited in the NCBI Gene Expression Omnibus (GEO) database under …