Role of cardiac macrophages on cardiac inflammation, fibrosis and tissue repair

WP Lafuse, DJ Wozniak, MVS Rajaram - Cells, 2020 - mdpi.com
… After tissue injury, monocytes and tissue-resident … regulators of tissue repair, regeneration
and fibrosis. Disturbance … can lead to aberrant repair, persistent injury, and HF. Therefore, in …

Autophagy, tissue repair, and fibrosis: a delicate balance

F Migneault, MJ Hébert - Matrix biology, 2021 - Elsevier
tissue remodeling to reestablish normal function and integrity. However, their persistent
accumulation at the site of injury is a hallmark of fibrosis. … at the site of tissue injury and repair. …

[HTML][HTML] Transforming growth factor–β in tissue fibrosis

NG Frangogiannis - Journal of Experimental Medicine, 2020 - rupress.org
… Induction and activation of TGF-β in tissue injury and fibrosis … in fibrotic tissues, regardless
of the etiology of the initial injury. … TGF-β isoform expression in fibrotic tissues. Neurohumoral …

Epithelial-mesenchymal transition (EMT): the type-2 EMT in wound healing, tissue regeneration and organ fibrosis

GD Marconi, L Fonticoli, TS Rajan, SD Pierdomenico… - Cells, 2021 - mdpi.com
… During organ fibrosis, type-2 EMT occurs as a reparative-associated process in … , fibrosis
and tissue regeneration, as well as some recent progresses in the EMT and tissue regeneration

Fibrosis following acute skeletal muscle injury: Mitigation and reversal potential in the clinic

T Gardner, K Kenter, Y Li - Journal of sports medicine, 2020 - Wiley Online Library
Tissue fibrosis is not an uncommon outcome after injury and is not isolated to the muscle
system. This common pathophysiologic outcome can offer potential medications for fibrosis

T lymphocytes as critical mediators in tissue regeneration, fibrosis, and the foreign body response

KM Adusei, TB Ngo, K Sadtler - Acta Biomaterialia, 2021 - Elsevier
… elicits a delicate balance between tissue repair and fibrosis that is mainly regulated by three
… of fibrosis or repair in different tissues. This review explores the fibrotic and regenerative T …

Macrophages in lung injury, repair, and fibrosis

P Cheng, S Li, H Chen - Cells, 2021 - mdpi.com
… The lungs are frequently exposed to microbes and pollutants, thus establishing environmental
adaptation that sustains immune tolerance, alleviates tissue injury, and secures gas …

[PDF][PDF] Principles of cell circuits for tissue repair and fibrosis

M Adler, A Mayo, X Zhou, RA Franklin, ML Meizlish… - IScience, 2020 - cell.com
Tissue injury initiates a dynamic process that involves an immune response, local … of
injury on fibrosis, we considered the response of the circuit to several scenarios: injury stimuli …

Current approaches targeting the wound healing phases to attenuate fibrosis and scarring

A El Ayadi, JW Jay, A Prasai - International journal of molecular sciences, 2020 - mdpi.com
… Cutaneous fibrosis results from suboptimal wound healing following significant tissue injury
such as severe burns, trauma, and major surgeries. Pathologic skin fibrosis results in scars …

[HTML][HTML] Immune cell landscaping reveals a protective role for regulatory T cells during kidney injury and fibrosis

F do Valle Duraes, A Lafont, M Beibel, K Martin… - JCI insight, 2020 - ncbi.nlm.nih.gov
… as a model to study kidney fibrosis after IRI injury, hereafter referred to as the “fibrosis model.”
We … To characterize the different phases following kidney injury, regeneration, and fibrosis