Obesity programs macrophages to support cancer progression

A Singh, SS Mayengbam, H Yaduvanshi, MR Wani… - Cancer research, 2022 - AACR
… microenvironment in obesity, adipose tissue macrophages (… of macrophages in obesity-influenced
cancer progression. … and macrophage infiltration in the breast tissue of obese women. …

The impact of adipose tissue–derived miRNAs in metabolic syndrome, obesity, and cancer

GS Heyn, LH Corrêa, KG Magalhães - Frontiers in endocrinology, 2020 - frontiersin.org
tissue macrophages from lean and obese mice, showing that the M1 macrophages were
prevalent in adipose tissue from obese … , in adipose tissue from lean mice, macrophages mostly …

Role of adipose tissue macrophages in obesity-related disorders

S Chakarov, C Blériot, F Ginhoux - Journal of Experimental Medicine, 2022 - rupress.org
… of the adipose tissue environment, while highlighting its heterogeneity. Finally, we detail
how obesity transforms both adipose tissue and local macrophage populations. Understanding …

New insights into adipose tissue macrophages in obesity and insulin resistance

Z Cai, Y Huang, B He - Cells, 2022 - mdpi.com
… of adipose tissue macrophages (ATMs) beyond classical M1/M2 polarization in obesity and
… diverse subpopulations of ATMs in the context of obesity. Furthermore, we review the recent …

The interplay between tissue niche and macrophage cellular metabolism in obesity

S Daemen, JD Schilling - Frontiers in immunology, 2020 - frontiersin.org
… Modulation of obesity and metabolic disorders by tissue macrophages. Tissue macrophages
can affect obesity and the development of associated metabolic disorders by affecting …

The obesity-breast cancer link: a multidisciplinary perspective

EN Devericks, MS Carson, LE McCullough… - Cancer and Metastasis …, 2022 - Springer
… and initiates adipose tissue fibrosis [57]. Adipose tissue macrophages engulf necrotic or …
CLS), a key feature of the pro-inflammatory process in adipose tissue [58]. Stressed adipose …

Obesity promotes cooperation of cancer stem-like cells and macrophages to enhance mammary tumor angiogenesis

LE Hillers-Ziemer, RQ McMahon, M Hietpas, G Paderta… - Cancers, 2020 - mdpi.com
… that obese breast cancer patients may have enhanced clinical benefit from macrophage-…
have been shown to promote angiogenesis in obese mammary tissue [32], we hypothesized …

Adipose tissue macrophage phenotypes and characteristics: the key to insulin resistance in obesity and metabolic disorders

Y Ni, L Ni, F Zhuge, L Xu, Z Fu, T Ota - Obesity, 2020 - Wiley Online Library
… , were shown to be effective for obesity-induced IR and other … of macrophages in adipose
tissue under conditions of obesitymacrophages might be a key therapeutic target for obesity-…

[HTML][HTML] Obesity and breast cancer: the role of crown-like structures in breast adipose tissue in tumor progression, prognosis, and therapy

SS Faria, LH Corrêa, GS Heyn… - … of breast cancer, 2020 - ncbi.nlm.nih.gov
… Moreover, adipose tissue macrophages are an important source of the proinflammatory
cytokines TNF-α and IL-6, which can block the insulin receptors, leading to insulin resistance [45]…

Obesity and breast cancer: a case of inflamed adipose tissue

R Kolb, W Zhang - Cancers, 2020 - mdpi.com
obesity and breast cancer. The aim of this review is to highlight the association between obesity
and breast cancer and … is due to chronic adipose tissue inflammation. We will discuss the …