… tumor necrosis factor receptors (TNFRs) to interfere with the biological effects of tumor necrosis
factor α (TNF-α… human progranulin (rhPGRN) in the gingival sulcus or bone defect area …

… progranulin (PGRN), a major modulator of microglial activity, plays a role in the progressive
damage following TBI. PGRN‐deficient … , the PGRN‐deficient mice showed overall stronger …

… to increased TNF-α signaling in CLL cells through binding TNFRs, preventing TNF-α-…
Notably, we observed that PGRN deficiency caused the aggregation of HexA (but not HexB) …

… In a mouse model of endotoxic shock, levels of TNF-α, IL-6, MCP-1, CIRP, and HMGB1 in
PGRN-deficient lungs were higher than those in WT lungs. Conversely, administration of …

… , progranulin (PGRN) is a unique ligand of TNF receptor (TNFR), which plays its anti-inflammatory
action mainly through TNF … Treg function, PGRN deficiency also interferes with the …

… Proangiogenic phenotype of progranulin deficient macrophages. a Immunofluorescent …
against TNF-α, C3, IL-1β, CCL2, and β-actin. c Quantitative analysis of expression level of TNF-α, …

… Among the multiple pro-inflammatory cytokines, TNF-α is at the peak of the inflammatory …
synaptic pruning might be a key factor that promotes synaptic deficit in PGRN deficiency. …

… In the biochemical pathogenesis of PCOS, the defect in the hypothalamic-pituitary-ovarian
axis is mainly held responsible. Axial defect causes an increase in gonadotropin-releasing …

… Progranulin is an antagonist of tumor necrosis factor (TNF) receptors (TNFRs) and is known
to promote inflammatory periodontal bone defect … via TNFR1 to inhibit TNF-α-sensitized NF-…

… in GRN haploinsufficiency, cause progranulin (PGRN)-deficient FTD characterized with …
PGRN deficiency in microglia was also found to upregulate NF-κB-TNFα signaling, resulting …