[HTML][HTML] Complexity of TNF-α signaling in heart disease

F Rolski, P Błyszczuk - Journal of clinical medicine, 2020 - mdpi.com
… of cardiovascular diseases in relation to modification of the TNF-α signaling pathway. …
models of cardiovascular diseases in relation to modification of the TNF-α signaling pathway. …

[HTML][HTML] The role of tumor necrosis factor alpha (TNF-α) in autoimmune disease and current TNF-α inhibitors in therapeutics

D Jang, AH Lee, HY Shin, HR Song, JH Park… - International journal of …, 2021 - mdpi.com
… induces the proliferation and anti-apoptosis of keratinocytes via the NF-κB signal pathway,
eventually leading to the formation of microabscess by enhancing the recruitment of …

[HTML][HTML] The dual role of tumor necrosis factor-alpha (TNF-α) in breast cancer: molecular insights and therapeutic approaches

D Cruceriu, O Baldasici, O Balacescu… - Cellular Oncology, 2020 - Springer
… of the p38/MAPK pro-proliferation pathway in T47D cells [63], … activities of TNF-α in relation
with the ER signaling pathway in … point between the TNF-α and ER signaling pathways, with a …

[HTML][HTML] Quercetin inhibits TNF-α induced HUVECs apoptosis and inflammation via downregulating NF-kB and AP-1 signaling pathway in vitro

T Chen, X Zhang, G Zhu, H Liu, J Chen, Y Wang, X He - Medicine, 2020 - journals.lww.com
… , such as TNF-α. One of the mechanisms is the MAPK signaling pathway, after being
phosphorylated, the c-Fos and c-jun proteins will be activated, following the activation of AP-1. …

[HTML][HTML] The role of IL-1β and TNF-α in intervertebral disc degeneration

Y Wang, M Che, J Xin, Z Zheng, J Li, S Zhang - Biomedicine & …, 2020 - Elsevier
… pattern and signal transduction pathways of IL-1β and TNF-α, and … Because IL-1β and TNF-α
inhibition have the potential to … Collectively, TNF-α induces a variety of signaling pathways

[HTML][HTML] The balance of TNF mediated pathways regulates inflammatory cell death signaling in healthy and diseased tissues

JD Webster, D Vucic - Frontiers in cell and developmental biology, 2020 - frontiersin.org
… survival and cell death inducing signaling. TNF stimulated signaling pathways are tightly
regulated by … of TNF receptors-associated intracellular signaling complexes. Disruption of these …

TNF-α and IL-6: the link between immune and bone system

T Wang, C He - Current drug targets, 2020 - ingentaconnect.com
… down-regulated in BMSCs enriched from TNFα transgenic mice, because of increased
Wwp1 mediated by TNF-α- signaling pathways. Wwp1 stimulates proteosomal degradation of …

[HTML][HTML] Death by TNF: a road to inflammation

G van Loo, MJM Bertrand - Nature Reviews Immunology, 2023 - nature.com
… the human and mouse TNF and TNF receptors were purified, … TNF were initiated to validate
its antitumour potential for cancer treatment (reviewed in 14 ). However, the hope that TNF

[HTML][HTML] Targeting TNF-α for COVID-19: recent advanced and controversies

Y Guo, K Hu, Y Li, C Lu, K Ling, C Cai… - Frontiers in public …, 2022 - frontiersin.org
… of TNF-α and IFN-γ. Collectively, the TNF-α signaling pathway plays a vital role in CRS (Figure
1)… Blocking the cytokine-mediated inflammatory cell death signaling pathway may benefit …

[HTML][HTML] Regulation of TNF-induced osteoclast differentiation

Z Yao, SJ Getting, IC Locke - Cells, 2021 - mdpi.com
… Considering the central role of OCs in bone diseases with bone loss, and the severe
rebound effect of denosumab discontinuation, we review the signaling pathways for RANKL-…