Inhibition of NF-κB and Wnt/β-catenin/GSK3β signaling pathways ameliorates cardiomyocyte hypertrophy and fibrosis in streptozotocin (STZ)-induced type 1 diabetic …

J Liu, L Shentu, N Ma, L Wang, G Zhang, Y Sun… - Current Medical …, 2020 - Springer
… -catenin/GSK3β pathways are activated … signaling pathways might improve myocardial injury
in diabetics. We therefore, in our present study, investigated the roles of these two pathways

[HTML][HTML] The role of the notch signaling pathway in recovery of cardiac function after myocardial infarction

O Kachanova, A Lobov, A Malashicheva - International Journal of …, 2022 - mdpi.com
… In this review, we consider the Notch signaling pathway as a potential target for therapeutic
… other signaling pathways. This review considers the role of the Notch signaling pathway in …

[HTML][HTML] Signaling pathways in rheumatoid arthritis: implications for targeted therapy

Q Ding, W Hu, R Wang, Q Yang, M Zhu, M Li… - Signal transduction and …, 2023 - nature.com
… researchers, the abnormal signaling pathways in RA are a … disease and various signaling
pathways and molecular mechanisms, … in identifying novel signaling pathways in RA and new …

Baicalin Inhibits Inflammation in Rats with Chronic Obstructive Pulmonary Disease by the TLR2/MYD88/NF‐κBp65 Signaling Pathway

J Ju, Z Li, Q Shi - Evidence‐Based Complementary and …, 2022 - Wiley Online Library
… The study has found that the TLR signaling pathwaysignaling pathway, MYD88 participates
in the occurrence and development of inflammation by transmitting upstream signaling

[HTML][HTML] TRPA1 promotes cisplatin-induced nephrotoxicity through inflammation mediated by the MAPK/NF-κB signaling pathway

J Yuan, X Liang, W Zhou, J Feng, Z Wang… - Annals of …, 2021 - ncbi.nlm.nih.gov
… To further confirm the inhibitory effect of DDP on the NF-κB signaling pathway, we detected
the expression of IL-1β, IL-6, TNF-α, and INF-γ by qRT-PCR, and the level of iNOS by …

[HTML][HTML] Signaling pathways of chronic kidney diseases, implications for therapeutics

Q Yuan, B Tang, C Zhang - Signal transduction and targeted therapy, 2022 - nature.com
… , and Notch signaling evoke the activation of myofibroblasts and promote the … these signaling
pathways are also introduced here. In this review, we update the key signaling pathways of …

Modulation of Keap-1/Nrf2/HO-1 and NF-ĸB/caspase-3 signaling pathways by Dihydromyricetin Ameliorates Sodium Valproate-Induced Liver Injury

D Emad, AMA Bayoumi, SM Gebril, DME Ali… - Archives of Biochemistry …, 2024 - Elsevier
… Additionally, DHM led to downregulation of proinflammatory factors in liver tissues,
including NF-ĸB, interleukin 1 beta (IL-1β), and tumor necrosis factor alpha (TNF-α). This was …

[HTML][HTML] The signal pathways and treatment of cytokine storm in COVID-19

L Yang, X Xie, Z Tu, J Fu, D Xu, Y Zhou - Signal transduction and …, 2021 - nature.com
… to understand the initiation and signaling pathways of CS to develop more … signaling, and
existing and potential interventions for targeting these cytokines or related signal pathways. We …

Danggui Buxue Tang Ameliorates Bleomycin‐Induced Pulmonary Fibrosis by Suppressing the TLR4/NLRP3 Signaling Pathway in Rats

J Wang, H Wang, F Fang, C Fang… - Evidence‐Based …, 2021 - Wiley Online Library
… actin (α-SMA) through the Smads signaling pathway and … in inhibiting inflammatory cytokines,
such as TNF-α and TGF-β1, in … related to TLR4/NLRP3 signaling pathway, which mediates …

[HTML][HTML] Cancer-associated fibroblasts promote radioresistance of breast cancer cells via the HGF/c-Met Signaling Pathway

B Wang, W Liu, C Liu, K Du, Z Guo, G Zhang… - International Journal of …, 2023 - Elsevier
… The CAFs were found to secrete HGF to activate the c-Met signaling pathway, which … /c-Met
signaling pathway activation. Moreover, radiation-induced tumor necrosis factor α (TNFα) …