[HTML][HTML] Are TrkB receptor agonists the right tool to fulfill the promises for a therapeutic value of the brain-derived neurotrophic factor?
M Zagrebelsky, M Korte - Neural Regeneration Research, 2024 - journals.lww.com
… , tropomyosin receptor … receptor kinase B receptor and not p75 neurotrophin receptor.
Therefore, while, based on the current knowledge, the tropomyosin receptor kinase B receptor …
Therefore, while, based on the current knowledge, the tropomyosin receptor kinase B receptor …
Nerve growth factor: The first molecule of the neurotrophin family
L Lorenzini, VA Baldassarro, A Stanzani… - Recent Advances in NGF …, 2021 - Springer
… aspects of NT biology and mechanisms of action have been discovered and clarified, … of
Trk activation by proNTs, recent studies suggest that proNGF can bind TrkA receptors with low …
Trk activation by proNTs, recent studies suggest that proNGF can bind TrkA receptors with low …
Neurotrophins and neurotrophin receptors
ML Franco, R Comaposada-Baró, M Vilar - Hormonal Signaling in Biology …, 2020 - Elsevier
… Trk receptors and p75NTR by mature neurotrophins results in cell survival, and selective
activation of p75NTR in the absence of Trk receptor … for the loss of NGF action on these cells. …
activation of p75NTR in the absence of Trk receptor … for the loss of NGF action on these cells. …
[HTML][HTML] BDNF receptor TrkB as the mediator of the antidepressant drug action
… (C) In Hebbian plasticity, active synapses are stabilized, whereas inactive ones are retracted,
and brain-derived neurotrophic factor (BDNF) through TrkB is a critical mediator in this …
and brain-derived neurotrophic factor (BDNF) through TrkB is a critical mediator in this …
[HTML][HTML] Antidepressant drugs act by directly binding to TRKB neurotrophin receptors
… We suggest that binding to TRKB and allosteric facilitation of BDNF signaling is the common
mechanism for antidepressant action, which may explain why typical antidepressants act …
mechanism for antidepressant action, which may explain why typical antidepressants act …
Roles of Trk receptors, tyrosine kinase receptors for neurotrophins, in the developing CNS
T Numakawa, H Odaka - Receptor Tyrosine Kinases in Neurodegenerative …, 2023 - Elsevier
… Considering the possible involvement of changed action of both MAPKs and neurotrophins/Trks
in the pathogenesis of neurogenerative diseases, understanding MAPK signaling …
in the pathogenesis of neurogenerative diseases, understanding MAPK signaling …
[HTML][HTML] Regulation of TrkB cell surface expression—a mechanism for modulation of neuronal responsiveness to brain-derived neurotrophic factor
T Andreska, P Lüningschrör, M Sendtner - Cell and tissue research, 2020 - Springer
… When brain-derived neurotrophic factor (BDNF) and the other members of the neurotrophin
… rather than differential expression of the corresponding TrkB receptor. In the present article, …
… rather than differential expression of the corresponding TrkB receptor. In the present article, …
[HTML][HTML] Transactivation of TrkB receptors by oxytocin and its G protein-coupled receptor
M Mitre, K Saadipour, K Williams, L Khatri… - Frontiers in Molecular …, 2022 - frontiersin.org
… Since TrkB is a predominant neurotrophin receptor … action and BDNF signaling through its
TrkB receptor, suggesting oxytocin may utilize downstream TrkB signaling for its actions. Other …
TrkB receptor, suggesting oxytocin may utilize downstream TrkB signaling for its actions. Other …
[HTML][HTML] Brain-derived neurotrophic factor signaling in depression and antidepressant action
E Castrén, LM Monteggia - Biological psychiatry, 2021 - Elsevier
… This study also reported that the Y433F mutation of the TrkB receptor blocks the binding …
TrkB receptor mutation also blocked ketamine’s effects on surface localization of AMPA receptors…
TrkB receptor mutation also blocked ketamine’s effects on surface localization of AMPA receptors…
Neurotrophin-3 modulates synaptic transmission
E Hernández-Echeagaray - Vitamins and hormones, 2020 - Elsevier
… neurotrophins whose actions are centered in the nervous system. NT-3 is structurally related
to other neurotrophins like brain-derived neurotrophic factor… of neurotrophin to Trk receptors …
to other neurotrophins like brain-derived neurotrophic factor… of neurotrophin to Trk receptors …
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