Development of new tuberculosis drugs: translation to regimen composition for drug-sensitive and multidrug-resistant tuberculosis

JP Ernest, N Strydom, Q Wang, N Zhang… - Annual review of …, 2021 - annualreviews.org
… of drug regimens and quantifying exposure-response relationships (14, 15). Comprehensive
data sets exist for drugs used as monotherapy and in combination with others (27–33). …

[HTML][HTML] Availability and costs of medicines for the treatment of tuberculosis in Europe

G Günther, L Guglielmetti, C Leu, C Lange… - Clinical microbiology …, 2023 - Elsevier
… We investigated the access to genotypic and phenotypic Mycobacterium tuberculosis drug
… confirmed availability of the drug; b detailed regimen composition is shown in Table S1 …

[HTML][HTML] The pipeline of new molecules and regimens against drug-resistant tuberculosis

TA Black, UK Buchwald - Journal of Clinical Tuberculosis and Other …, 2021 - Elsevier
… demonstrated for the first time that certain forms of drug-resistant tuberculosis can be cured
… these drugs may further advance optimized regimen compositions. Investigational drugs in …

[HTML][HTML] Value of pyrazinamide for composition of new treatment regimens for multidrug-resistant Mycobacterium tuberculosis in China

H Xia, S van Den Hof, F Cobelens, Y Zhou… - BMC Infectious …, 2020 - Springer
… -line drug with bactericidal activity, has an important role in the treatment of both drug-susceptible
and drug-resistant tuberculosis. Although its role in the longer MDR-TB regimen has …

Safety implications of combined antiretroviral and anti-tuberculosis drugs

M Cerrone, M Bracchi, S Wasserman… - … opinion on drug …, 2020 - Taylor & Francis
… focusing on drug safety of agents used in drug-sensitive TB … of drugs recommended for the
treatment of DR- and latent TB in … The recommended composition of treatment regimens for …

Cost and availability of drugs and treatment regimens and availability of drug resistance testing for tuberculosis in Europe

G Günther, L Guglielmetti, C Leu, C Lange, F van Leth… - medRxiv, 2022 - medrxiv.org
… DST and the costs and availability of anti-tuberculosis drugs and regimen, we performed a
… and ATS/CDC/IDSA/ERS 15 , whereas other regimen compositions could also be possible. …

Standardised shorter regimens versus individualised longer regimens for rifampin-or multidrug-resistant tuberculosis

S Abidi, J Achar, MMA Neino, D Bang… - European …, 2020 - Eur Respiratory Soc
… longer regimens to those whose composition met 2018 WHO guidelines by using at least
three drugs from group A (moxifloxacin/levofloxacin, bedaquiline, linezolid) plus at least one …

[图书][B] WHO consolidated guidelines on tuberculosis. Module 4: treatment-drug-resistant tuberculosis treatment

World Health Organization - 2020 - books.google.com
drug-resistant tuberculosis drug susceptibility testing electrocardiogram Electronic … of
specific drug compositions and combinations of different regimen durations (3–12). Patients with …

The pharmacotherapeutic management of pulmonary tuberculosis: an update of the state-of-the-art

G Fekadu, DY Chow, JHS You - Expert Opinion on …, 2022 - Taylor & Francis
… The 2020 WHO guidelines updated the composition of longer regimens for MDR/RR-TB with
a 3-group approach: Group A medicines are bedaquiline, levofloxacin or moxifloxacin, and …

[HTML][HTML] … Review on Long vs. Short Regimens in Multidrug-Resistant Tuberculosis (MDR-TB) Under Programmatic Management of Drug-Resistant Tuberculosis  …

A Karnan, U Jadhav, B Ghewade, A Ledwani… - Cureus, 2024 - ncbi.nlm.nih.gov
… shorter regimens to individualized regimens of a longer composition, aligning with WHO
guidelines for MDR-TB treatment [8]. Ongoing research endeavors aim to discern the optimal …