Covalent inhibitors: an opportunity for rational target selectivity

R Lagoutte, R Patouret, N Winssinger - Current opinion in chemical biology, 2017 - Elsevier
There is a resurging interest in compounds that engage their target through covalent
interactions. Cysteine's thiol is endowed with enhanced reactivity, making it the nucleophile …

[引用][C] Covalent inhibitors: an opportunity for rational target selectivity

R Lagoutte, R Patouret, N Winssinger - Current Opinion in Chemical …, 2017 - cir.nii.ac.jp
Covalent inhibitors: an opportunity for rational target selectivity | CiNii Research CiNii 国立
情報学研究所 学術情報ナビゲータ[サイニィ] 詳細へ移動 検索フォームへ移動 論文・データをさがす …

Covalent inhibitors: an opportunity for rational target selectivity.

R Lagoutte, R Patouret, N Winssinger - Current opinion in chemical …, 2017 - folia.unifr.ch
English There is a resurging interest in compounds that engage their target through covalent
interactions. Cysteine's thiol is endowed with enhanced reactivity, making it the nucleophile …

[PDF][PDF] Covalent inhibitors: an opportunity for rational target selectivity

R Lagoutte, R Patouret… - Current Opinion in …, 2017 - researchgate.net
Introduction Despite the historical success of covalent inhibitors, most HTS libraries have
been pruned of molecules with mildly reactive functionalities with potential for covalent …

[PDF][PDF] Covalent inhibitors: an opportunity for rational target selectivity

R Lagoutte, R Patouret, N Winssinger - access.archive-ouverte.unige.ch
There is a resurging interest in compounds that engage their target through covalent
interactions. Cysteine's thiol is endowed with enhanced reactivity, making it the nucleophile …

Covalent inhibitors: an opportunity for rational target selectivity.

R Lagoutte, R Patouret, N Winssinger - Current opinion in chemical …, 2017 - sonar.ch
English There is a resurging interest in compounds that engage their target through covalent
interactions. Cysteine's thiol is endowed with enhanced reactivity, making it the nucleophile …

Covalent inhibitors: an opportunity for rational target selectivity.

R Lagoutte, R Patouret, N Winssinger - Current Opinion in Chemical …, 2017 - europepmc.org
There is a resurging interest in compounds that engage their target through covalent
interactions. Cysteine's thiol is endowed with enhanced reactivity, making it the nucleophile …

Covalent inhibitors: an opportunity for rational target selectivity

R Lagoutte, R Patouret… - Current opinion in …, 2017 - pubmed.ncbi.nlm.nih.gov
There is a resurging interest in compounds that engage their target through covalent
interactions. Cysteine's thiol is endowed with enhanced reactivity, making it the nucleophile …