Loss of MeCP2 in adult 5-HT neurons induces 5-HT1A autoreceptors, with opposite sex-dependent anxiety and depression phenotypes

TJ Philippe, F Vahid-Ansari, ZR Donaldson… - Scientific …, 2018 - ecommons.aku.edu
The 5-HT1A autoreceptor mediates feedback inhibition of serotonin (5-HT) neurons, and is
implicated in major depression. The human 5-HT1A gene (HTR1A) rs6295 risk allele …
[PDF] zdonaldsonlab.com

[PDF][PDF] Loss of MeCP2 in adult 5-HT neurons induces 5-HT1A autoreceptors, with opposite sex-dependent anxiety and depression phenotypes

TJ Philippe, F Vahid-Ansari, ZR Donaldson… - SCIeNTIFIC …, 2018 - zdonaldsonlab.com
Results Deaf1-MeCP2 interaction enhances recruitment to the HTR1A promoter. Because
methylation of the Deaf1 site of the 5-HT1A gene is associated with negative symptoms of …