[HTML][HTML] Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI

C Li, KM Voos, M Pathak, G Hall, KR McCrae… - Journal of Thrombosis …, 2019 - Elsevier
Essentials• Zymogen PK is activated to PKa and cleaves substrates kininogen and FXII
contributing to bradykinin generation.• Monomeric PKa and dimeric homologue FXI utilize …

[HTML][HTML] Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI

C Li, KM Voos, M Pathak, G Hall… - … of Thrombosis and …, 2019 - ncbi.nlm.nih.gov
Background Plasma prekallikrein (PK) and factor XI (FXI) are apple domain‐containing
serine proteases that when activated to PK a and FXI a cleave substrates kininogen, factor …

[PDF][PDF] Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI

C LI, KM VOOS, M PATHAK, G HALL… - Journal of Thrombosis …, 2019 - core.ac.uk
Background: Plasma prekallikrein (PK) and factor XI (FXI) are apple domain-containing
serine proteases that when activated to PKa and FXIa cleave substrates kininogen, factor …

Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI

C Li, KM Voos, M Pathak, G Hall… - … of thrombosis and …, 2019 - pubmed.ncbi.nlm.nih.gov
Essentials Zymogen PK is activated to PKa and cleaves substrates kininogen and FXII
contributing to bradykinin generation. Monomeric PKa and dimeric homologue FXI utilize the …

[HTML][HTML] Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI

C Li, KM Voos, M Pathak, G Hall, KR McCrae… - Journal of Thrombosis …, 2019 - jthjournal.org
Unlabelled Box• Zymogen PK is activated to PKa and cleaves substrates kininogen and FXII
contributing to bradykinin generation.• Monomeric PKa and dimeric homologue FXI utilize …

Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI.

C Li, KM Voos, M Pathak, G Hall… - … of Thrombosis and …, 2019 - europepmc.org
Background Plasma prekallikrein (PK) and factor XI (FXI) are apple domain‐containing
serine proteases that when activated to PK a and FXI a cleave substrates kininogen, factor …

Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI

C Li, KM Voos, M Pathak, G Hall… - … of Thrombosis and …, 2019 - Wiley Online Library
Essentials Zymogen PK is activated to PKa and cleaves substrates kininogen and FXII
contributing to bradykinin generation. Monomeric PKa and dimeric homologue FXI utilize the …

Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI

C Li, KM Voos, M Pathak, G Hall, KR Mccrae… - Journal of Thrombosis …, 2019 - hero.epa.gov
Essentials Zymogen PK is activated to PKa and cleaves substrates kininogen and FXII
contributing to bradykinin generation. Monomeric PKa and dimeric homologue FXI utilize the …

Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI

C Li, KM Voos, M Pathak, G Hall… - Journal of … - nottingham-repository.worktribe.com
Background Plasma prekallikrein (PK) and factor XI (FXI) are apple domain‐containing
serine proteases that when activated to PKa and FXIa cleave substrates kininogen, factor …

Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI.

C Li, KM Voos, M Pathak, G Hall… - … of Thrombosis and …, 2019 - europepmc.org
Background Plasma prekallikrein (PK) and factor XI (FXI) are apple domain‐containing
serine proteases that when activated to PK a and FXI a cleave substrates kininogen, factor …