Low cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens

B Mishra, J Lakshmaiah Narayana… - Proceedings of the …, 2019 - National Acad Sciences
As bacterial resistance to traditional antibiotics continues to emerge, new alternatives are
urgently needed. Antimicrobial peptides (AMPs) are important candidates. However, how …

Low cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens

B Mishra, J Lakshmaiah Narayana… - Proceedings of the …, 2019 - ui.adsabs.harvard.edu
New strategies are required to develop the next generation of peptide antibiotics. This study
has advanced our understanding by discovering an important factor that determines in vivo …

Low cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens

B Mishra, JL Narayana, T Lushnikova… - Proceedings of the …, 2019 - experts.nebraska.edu
As bacterial resistance to traditional antibiotics continues to emerge, new alternatives are
urgently needed. Antimicrobial peptides (AMPs) are important candidates. However, how …

Low cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens

B Mishra, JL Narayana… - Proceedings of the …, 2019 - pubmed.ncbi.nlm.nih.gov
As bacterial resistance to traditional antibiotics continues to emerge, new alternatives are
urgently needed. Antimicrobial peptides (AMPs) are important candidates. However, how …

Low cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens.

B Mishra, T Lushnikova, X Wang… - Proceedings of the …, 2019 - europepmc.org
Results Peptide Optimization and In Vitro Testing. Our main goal is to identify peptides that
display in vivo efficacy in a systemic mouse model (outlined in Fig. 1A). There are multiple …

[HTML][HTML] Low cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens

B Mishra, JL Narayana, T Lushnikova… - Proceedings of the …, 2019 - ncbi.nlm.nih.gov
Results Peptide Optimization and In Vitro Testing. Our main goal is to identify peptides that
display in vivo efficacy in a systemic mouse model (outlined in Fig. 1A). There are multiple …

Low cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens

B Mishra, JL Narayana, T Lushnikova, X Wang… - Proceedings of the …, 2019 - JSTOR
As bacterial resistance to traditional antibiotics continues to emerge, new alternatives are
urgently needed. Antimicrobial peptides (AMPs) are important candidates. However, how …