Cellular resistance mechanisms to targeted protein degradation converge toward impairment of the engaged ubiquitin transfer pathway

P Ottis, C Palladino, P Thienger, A Britschgi… - ACS chemical …, 2019 - ACS Publications
Proteolysis targeting chimeras are bifunctional small molecules capable of recruiting a target
protein of interest to an E3 ubiquitin ligase that facilitates target ubiquitination followed by …
被引用次数：116 相关文章

Cellular Resistance Mechanisms to Targeted Protein Degradation Converge Toward Impairment of the Engaged Ubiquitin Transfer Pathway.

P Ottis, C Palladino, P Thienger, A Britschgi… - ACS Chemical …, 2019 - europepmc.org
Proteolysis targeting chimeras are bifunctional small molecules capable of recruiting a target
protein of interest to an E3 ubiquitin ligase that facilitates target ubiquitination followed by …
[PDF] academia.edu

[PDF][PDF] Cellular Resistance Mechanisms to Targeted Protein Degradation Converge Toward Impairment of the Engaged Ubiquitin Transfer Pathway

P Ottis, C Palladino, P Thienger, A Britschgi… - academia.edu
N-terminal tagging of endogenous BRD4 with HiBit-tag in HEK293A cells was performed
according to1. Briefly, sgRNA (guide sequence 5'-ATCCCATCACATTCT-TCACC-3') was …

Cellular Resistance Mechanisms to Targeted Protein Degradation Converge Toward Impairment of the Engaged Ubiquitin Transfer Pathway

P Ottis, C Palladino, P Thienger… - ACS chemical …, 2019 - pubmed.ncbi.nlm.nih.gov
Proteolysis targeting chimeras are bifunctional small molecules capable of recruiting a target
protein of interest to an E3 ubiquitin ligase that facilitates target ubiquitination followed by …