The MUC1–HIF-1α signaling axis regulates pancreatic cancer pathogenesis through polyamine metabolism remodeling

D Murthy, KS Attri, V Suresh… - Proceedings of the …, 2024 - National Acad Sciences
Dysregulation of polyamine metabolism has been implicated in cancer initiation and
progression; however, the mechanism of polyamine dysregulation in cancer is not fully …

The MUC1-HIF-1α signaling axis regulates pancreatic cancer pathogenesis through polyamine metabolism remodeling.

D Murthy, KS Attri, V Suresh… - Proceedings of the …, 2024 - europepmc.org
Polyamine homeostasis is critical for maintaining cellular functions (6, 11). The polyamine
pathway metabolites are derived from ornithine metabolism (Fig. 1A). Both intracellular and …

The MUC1-HIF-1α signaling axis regulates pancreatic cancer pathogenesis through polyamine metabolism remodeling

D Murthy, KS Attri, V Suresh… - Proceedings of the …, 2024 - ui.adsabs.harvard.edu
Pancreatic cancer is a devastating disease with limited treatment options and poor
prognosis. This study uncovers a link between MUC1/hypoxia-inducible factor-1α (HIF-1α) …

The MUC1-HIF-1α signaling axis regulates pancreatic cancer pathogenesis through polyamine metabolism remodeling

D Murthy, KS Attri, V Suresh… - Proceedings of the …, 2024 - experts.nebraska.edu
Dysregulation of polyamine metabolism has been implicated in cancer initiation and
progression; however, the mechanism of polyamine dysregulation in cancer is not fully …

[HTML][HTML] The MUC1–HIF-1α signaling axis regulates pancreatic cancer pathogenesis through polyamine metabolism remodeling

D Murthy, KS Attri, V Suresh… - Proceedings of the …, 2024 - ncbi.nlm.nih.gov
Polyamine homeostasis is critical for maintaining cellular functions (6, 11). The polyamine
pathway metabolites are derived from ornithine metabolism (Fig. 1A). Both intracellular and …

The MUC1-HIF-1α signaling axis regulates pancreatic cancer pathogenesis through polyamine metabolism remodeling

D Murthy, KS Attri, V Suresh… - Proceedings of the …, 2024 - pubmed.ncbi.nlm.nih.gov
Dysregulation of polyamine metabolism has been implicated in cancer initiation and
progression; however, the mechanism of polyamine dysregulation in cancer is not fully …

The MUC1-HIF-1α signaling axis regulates pancreatic cancer pathogenesis through polyamine metabolism remodeling.

D Murthy, KS Attri, V Suresh… - Proceedings of the …, 2024 - europepmc.org
Dysregulation of polyamine metabolism has been implicated in cancer initiation and
progression; however, the mechanism of polyamine dysregulation in cancer is not fully …

The MUC1–HIF-1α signaling axis regulates pancreatic cancer pathogenesis through polyamine metabolism remodeling

D Murthy, KS Attri, V Suresh… - Proceedings of the …, 2024 - experts.nebraska.edu
Dysregulation of polyamine metabolism has been implicated in cancer initiation and
progression; however, the mechanism of polyamine dysregulation in cancer is not fully …