Apelin-13 protects dopaminergic neurons in MPTP-induced Parkinson's disease model mice through inhibiting endoplasmic reticulum stress and promoting …
J Zhu, S Dou, Y Jiang, J Chen, C Wang, B Cheng - Brain Research, 2019 - Elsevier
… The dopaminergic neurodegeneration in the substantia nigrapars compacta (SNpc) and
striatum of the midbrain is the important pathological feature of Parkinson's disease (PD). It has …
striatum of the midbrain is the important pathological feature of Parkinson's disease (PD). It has …
[HTML][HTML] Neuroprotective effects of cryptotanshinone in a direct reprogramming model of Parkinson's disease
… However, rodent models may not sufficiently represent the … These results suggest that the
CTN potentially protects cells … pathogenesis, although they are known to remain rejuvenated …
CTN potentially protects cells … pathogenesis, although they are known to remain rejuvenated …
Parkinson's disease, aging and adult neurogenesis: Wnt/β‐catenin signalling as the key to unlock the mystery of endogenous brain repair
B Marchetti, C Tirolo, F L'Episcopo, S Caniglia… - Aging cell, 2020 - Wiley Online Library
… impaired neurogenic niches to rejuvenate and repair the aged … in aging mice and to protect
nigrostriatal DAergic neurons in … Of specific interest, in MPTP-aged mouse model of PD we …
nigrostriatal DAergic neurons in … Of specific interest, in MPTP-aged mouse model of PD we …
[HTML][HTML] Effects of grape polyphenols on the life span and neuroinflammatory alterations related to neurodegenerative parkinson disease-like disturbances in mice
MA Tikhonova, NG Tikhonova, MV Tenditnik… - Molecules, 2020 - mdpi.com
… /6 mice and on behavioral and neuroinflammatory alterations in a transgenic mouse model of
Parkinson disease (PD… and natural antioxidants that can protect human cells from oxidative …
Parkinson disease (PD… and natural antioxidants that can protect human cells from oxidative …
The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease
E Ilijic, JN Guzman, DJ Surmeier - Neurobiology of disease, 2011 - Elsevier
… Theoretically, the ideal DHP for protecting SNc DA neurons would be one that was selective
… that isradipine would protect SNc DA neurons and fibers in a progressive model of PD …
… that isradipine would protect SNc DA neurons and fibers in a progressive model of PD …
The ongoing pursuit of neuroprotective therapies in Parkinson disease
D Athauda, T Foltynie - Nature Reviews Neurology, 2015 - nature.com
… of the pathogenesis of Parkinson disease (PD), lack of accurate animal models and validated
… Moreover, statins have been shown to protect dopaminergic neurons from inflammatory …
… Moreover, statins have been shown to protect dopaminergic neurons from inflammatory …
[HTML][HTML] … antioxidant self-defenses by grafting astrocytes rejuvenates the aged microenvironment and mitigates nigrostriatal toxicity in Parkinsonian brain via an Nrf2 …
MF Serapide, F L'Episcopo, C Tirolo, N Testa… - Frontiers in Aging …, 2020 - frontiersin.org
… are being pursued to develop novel therapeutic regimens for PD, including cell therapies,
aimed at protecting or enhancing the intrinsic regenerative potential of DAergic neurons. …
aimed at protecting or enhancing the intrinsic regenerative potential of DAergic neurons. …
Neuroprotective Effect of Long-term NDI1 Gene Expression in a Chronic Mouse Model of Parkinson Disorder
J Barber-Singh, B Boo Seo… - Rejuvenation …, 2009 - liebertpub.com
… to protect the dopaminergic neurons in a chronic mouse model of Parkinson disorder. After
… nigra of male C57BL/6 mice for 8 months, a chronic Parkinsonian model was created by …
… nigra of male C57BL/6 mice for 8 months, a chronic Parkinsonian model was created by …
[HTML][HTML] Plant-derived neuroprotective agents in Parkinson's disease
… can protect dopaminergic neurons from neuronal degeneration, … neurons and the loss of
DA axons in the striatum were significantly suppressed by curcumin in the MPTP mouse model […
DA axons in the striatum were significantly suppressed by curcumin in the MPTP mouse model […
[PDF][PDF] Neuroprotection in Parkinson's Disease: A Systematic Review of the Preclinical Data.
… They discovered that resveratrol was not only capable of protecting neurons, … Animal
models of Parkinson’s disease: a source of novel treatments and clues to the cause of the disease…
models of Parkinson’s disease: a source of novel treatments and clues to the cause of the disease…