Apelin-13 protects dopaminergic neurons in MPTP-induced Parkinson's disease model mice through inhibiting endoplasmic reticulum stress and promoting …

J Zhu, S Dou, Y Jiang, J Chen, C Wang, B Cheng - Brain Research, 2019 - Elsevier
… The dopaminergic neurodegeneration in the substantia nigrapars compacta (SNpc) and
striatum of the midbrain is the important pathological feature of Parkinson's disease (PD). It has …

[HTML][HTML] Neuroprotective effects of cryptotanshinone in a direct reprogramming model of Parkinson's disease

JE Lee, H Sim, HM Yoo, M Lee, A Baek, YJ Jeon… - Molecules, 2020 - mdpi.com
… However, rodent models may not sufficiently represent the … These results suggest that the
CTN potentially protects cells … pathogenesis, although they are known to remain rejuvenated

Parkinson's disease, aging and adult neurogenesis: Wnt/β‐catenin signalling as the key to unlock the mystery of endogenous brain repair

B Marchetti, C Tirolo, F L'Episcopo, S Caniglia… - Aging cell, 2020 - Wiley Online Library
… impaired neurogenic niches to rejuvenate and repair the aged … in aging mice and to protect
nigrostriatal DAergic neurons in … Of specific interest, in MPTP-aged mouse model of PD we …

[HTML][HTML] Effects of grape polyphenols on the life span and neuroinflammatory alterations related to neurodegenerative parkinson disease-like disturbances in mice

MA Tikhonova, NG Tikhonova, MV Tenditnik… - Molecules, 2020 - mdpi.com
… /6 mice and on behavioral and neuroinflammatory alterations in a transgenic mouse model of
Parkinson disease (PD… and natural antioxidants that can protect human cells from oxidative …

The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease

E Ilijic, JN Guzman, DJ Surmeier - Neurobiology of disease, 2011 - Elsevier
… Theoretically, the ideal DHP for protecting SNc DA neurons would be one that was selective
… that isradipine would protect SNc DA neurons and fibers in a progressive model of PD …

The ongoing pursuit of neuroprotective therapies in Parkinson disease

D Athauda, T Foltynie - Nature Reviews Neurology, 2015 - nature.com
… of the pathogenesis of Parkinson disease (PD), lack of accurate animal models and validated
… Moreover, statins have been shown to protect dopaminergic neurons from inflammatory …

[HTML][HTML] … antioxidant self-defenses by grafting astrocytes rejuvenates the aged microenvironment and mitigates nigrostriatal toxicity in Parkinsonian brain via an Nrf2 …

MF Serapide, F L'Episcopo, C Tirolo, N Testa… - Frontiers in Aging …, 2020 - frontiersin.org
… are being pursued to develop novel therapeutic regimens for PD, including cell therapies,
aimed at protecting or enhancing the intrinsic regenerative potential of DAergic neurons. …

Neuroprotective Effect of Long-term NDI1 Gene Expression in a Chronic Mouse Model of Parkinson Disorder

J Barber-Singh, B Boo Seo… - Rejuvenation …, 2009 - liebertpub.com
… to protect the dopaminergic neurons in a chronic mouse model of Parkinson disorder. After
… nigra of male C57BL/6 mice for 8 months, a chronic Parkinsonian model was created by …

[HTML][HTML] Plant-derived neuroprotective agents in Parkinson's disease

W Fu, W Zhuang, S Zhou, X Wang - American journal of …, 2015 - ncbi.nlm.nih.gov
… can protect dopaminergic neurons from neuronal degeneration, … neurons and the loss of
DA axons in the striatum were significantly suppressed by curcumin in the MPTP mouse model […

[PDF][PDF] Neuroprotection in Parkinson's Disease: A Systematic Review of the Preclinical Data.

H Douna, BM Bavelaar, H Pellikaan… - The Open …, 2012 - research.vumc.nl
… They discovered that resveratrol was not only capable of protecting neurons, … Animal
models of Parkinson’s disease: a source of novel treatments and clues to the cause of the disease