β2adrenoceptor agonists: current and future direction

M Cazzola, L Calzetta… - British journal of …, 2011 - Wiley Online Library
… Despite the passionate debate over the use of β 2 -adrenoceptor agonists in the … β 2 -adrenoceptor
agonists with long half-lives, also called ultra long-acting β 2 -adrenoceptor agonists (…

[HTML][HTML] Past, present and futureβ2-adrenoceptor agonists in asthma management

MR Sears, J Lötvall - Respiratory medicine, 2005 - Elsevier
β 2 -adrenoceptor agonist bronchodilators ( β 2 -agonists) are … acting and long-acting β 2
-agonists, such classifications may not … β -adrenoceptor agonists ( β -agonists), one of the oldest …

β-Adrenoceptor modulation in chronic obstructive pulmonary disease: present and future perspectives

MG Matera, L Calzetta, M Cazzola - Drugs, 2013 - Springer
agonists and the issues of β-AR blockade and cardioselectivity in patients with comorbid CVD.
We then summarize the current … Finally, we provide a view of the future landscape in terms …

Current therapeutic uses and potential of β-adrenoceptor agonists and antagonists

G Emilien, JM Maloteaux, G Emilion - European journal of clinical …, 1998 - Springer
… Atypical b-adrenoceptors or b3-adrenoceptors, which are present … b2-Adrenoceptor agonists
have played a key role in the … We suggest that future clinical studies of b-receptors should …

Bronchodilators: current and future

M Cazzola, MG Matera - Clinics in Chest Medicine, 2014 - chestmed.theclinics.com
… It is likely that an approach using muscarinic antagonist β 2 -agonist (MABA) molecules
will provide the best opportunity to develop combinations that combine corticosteroids with 2 …

Glucocorticosteroids: current and future directions

PJ Barnes - British journal of pharmacology, 2011 - Wiley Online Library
… Glucocorticoids may also enhance the coupling of β 2 -receptors to G-protein (G s ), thus
enhancing β 2 -agonist effects and reversing the uncoupling of β 2 -receptors that may occur in …

Recent advances in the identification of a 1-and a 2-adrenoceptor subtypes: therapeutic implications

JP Hieble, RR Ruffolo - Expert Opinion on Investigational Drugs, 1997 - Taylor & Francis
agonists are now being employed for a variety of therapeutic applications, most involving
actions on receptors … α2-adrenoceptor agonists for these applications, recent gene mutation/…

Cardiovascular pharmacogenomics of adrenergic receptor signaling: clinical implications and future directions

JA Johnson, SB Liggett - Clinical Pharmacology & Therapeutics, 2011 - Wiley Online Library
… We also highlight the additional insights from studies of genes that encode GPCR
signaling or regulatory proteins and discuss current implications and future challenges. These …

β-Adrenoceptor agonists and asthma—100 years of development

B Waldeck - European journal of pharmacology, 2002 - Elsevier
… More recent research has revealed that there are genetic variations of the … to β 2 -adrenoceptor
agonists. Thus it was found that in an asthmatic cohort, five different β 2 -adrenoceptor

β2 Agonists

CK Billington, RB Penn, IP Hall - … and Therapeutics of Asthma and COPD, 2017 - Springer
… of β agonist use (pharmacogenetics). Finally we comment on what the future may hold for the
use of β agonists in … classes of β agonists available and consider their current clinical use. …