3xTgAD mice exhibit altered behavior and elevated Aβ after chronic mild social stress

SM Rothman, N Herdener, S Camandola, SJ Texel… - Neurobiology of …, 2012 - Elsevier
3xTgAD mice display vulnerability to chronic stress and whether chronic stress exacerbates
AD pathology and behavioral … 6-hour stress period 3xTgAD mice experienced a sustained …

3xTg-AD mice exhibit an activated central stress axis during early-stage pathology

EK Hebda-Bauer, TA Simmons, A Sugg… - Journal of …, 2013 - content.iospress.com
… when 3xTg-AD mice show mild behavioral changes, suggesting … observed mild altered
emotionality in six-month-old 3xTg-AD micesocial stress as evidenced by elevated CORT levels …

Endocrine stress responsivity and social memory in 3xTg-AD female and male mice: A tale of two experiments

ET Nguyen, D Selmanovic, M Maltry, R Morano… - … and Behavior, 2020 - Elsevier
… heightened stress-induced corticosterone levels and … Although 3xTg-AD mice do not
display elevated basal … 3xTg mice (ie, 4 months) already exhibit altered mRNA expression of …

Age-related changes in social behaviours in the 5xFAD mouse model of Alzheimer's disease

F Kosel, PT Munoz, JR Yang, AA Wong… - Behavioural Brain …, 2019 - Elsevier
… Evidence for increased sociability in the 3xTg-AD mouse … accelerated pathology, transgenic
5xFAD mice exhibit deficits … exhibit abnormal responses to social odour cues and altered

[HTML][HTML] Investigation of anxiety-and depressive-like symptoms in 4-and 8-month-old male triple transgenic mouse models of Alzheimer's disease

D Várkonyi, B Török, E Sipos, CL Fazekas… - International Journal of …, 2022 - mdpi.com
… in the 3xTg-AD mice immobility latency was increased at 8-… results, 4-month-old 3xTg-AD
mice reacted to stress with an … that some behavioral characteristics of 3xTg-AD mice might be …

Chronic mild sleep restriction accentuates contextual memory impairments, and accumulations of cortical and pTau in a mouse model of Alzheimer's disease

SM Rothman, N Herdener, KA Frankola, MR Mughal… - Brain research, 2013 - Elsevier
… of oligomers and pTau were not significantly changed in … to cause a sustained level of
stress in 3xTgAD mice. In studies … to acclimate to social stress, 3xTgAD mice also display an …

Age and gender differences for the behavioral phenotypes of 3xTg Alzheimer's disease mice

T Pairojana, S Phasuk, P Suresh, SP Huang… - Brain Research, 2021 - Elsevier
… Male 3xTg-AD mice exhibit normal sensory and locomotor … behavioral phenotypes for the
two genders of 3xTg-AD mice at … In 3xTg-AD mice, plaques occur at around three months old…

[HTML][HTML] Differential effects of chronic immunosuppression on behavioral, epigenetic, and Alzheimer's disease-associated markers in 3xTg-AD mice

M Kapadia, MF Mian, D Ma, CP Hutton, A Azam… - Alzheimer's Research & …, 2021 - Springer
… early manifestations of systemic autoimmunity, increased … to 3xTg-AD males, 1-year-old
3xTg-AD females still show … in the context of the altered 3xTg-AD phenotype, the current study …

[HTML][HTML] Impact of chronic risperidone use on behavior and survival of 3xTg-AD mice model of Alzheimer's disease and mice with normal aging

V Torres-Lista, S López-Pousa… - Frontiers in …, 2019 - frontiersin.org
… the 3xTg-AD (s) mice, an increase in the number of “changed3xTg-AD mice and their worse
capacity to cope with stress; … decreased the number of plaques of in the cortex and in the …

IL-6 trans-signaling in the brain influences the behavioral and physio-pathological phenotype of the Tg2576 and 3xTgAD mouse models of Alzheimer's disease

A Escrig, C Canal, P Sanchis… - Brain, Behavior, and …, 2019 - Elsevier
… traits changed similarly in AD mice, with the exception of … male and female mice showed
increased exploratory behavior in the … , 40 and 42 levels were much lower in the 3xTg-AD