[图书][B] Hippocampal Dysfunction in the 3xTgAD Mouse Model of Alzheimer's Disease
K Davis - 2012 - search.proquest.com
… the 3xTgAD mouse was used as a high fidelity model of human AD pathological progression
to study the function of HF during early (intracellular Aβ… in their SA behaviour, suggesting no …
to study the function of HF during early (intracellular Aβ… in their SA behaviour, suggesting no …
Administration of NaHS attenuates footshock-induced pathologies and emotional and cognitive dysfunction in triple transgenic Alzheimer's mice
HJ Huang, SL Chen, HM Hsieh-Li - Frontiers in Behavioral …, 2015 - frontiersin.org
… that footshock significantly increased the level of Aβ in area … that footshock with SRs did not
alter inflammatory-related pathways, … Chronic stress, BACE1, and Aβ participate in a positive …
alter inflammatory-related pathways, … Chronic stress, BACE1, and Aβ participate in a positive …
Insoluble Aβ overexpression in an App knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, affecting anxiety-related …
E Pervolaraki, SP Hall, D Foresteire… - Disease models & …, 2019 - journals.biologists.com
… significantly altered, but MD, AxD and RD were all increased … In both cases, aged 3xTg-AD
mice (>12 months old) have … that explain the altered behaviour in App NL-GF KI mice, our …
mice (>12 months old) have … that explain the altered behaviour in App NL-GF KI mice, our …
Deregulation of hypothalamic-pituitary-adrenal axis functions in an Alzheimer's disease rat model
A Brureau, C Zussy, B Delair, C Ogier, G Ixart… - Neurobiology of …, 2013 - Elsevier
… Aβ 25–35 induces memory impairment, alteration of anxiety … Chronic behavioral stress
enhanced plaque pathology and … In our study, GR expression was increased 1 week after Aβ 25–…
enhanced plaque pathology and … In our study, GR expression was increased 1 week after Aβ 25–…
Cognitive, behavioral and metabolic effects of oral galactose treatment in the transgenic Tg2576 mice
… altered expressions of around 20 genes in both mouse models, but the genes related to synaptic
function were dysregulated in the 3xTg AD mice… treatment markedly increased Aβ levels …
function were dysregulated in the 3xTg AD mice… treatment markedly increased Aβ levels …
Repeated cognitive stimulation alleviates memory impairments in an Alzheimer's disease mouse model
ST Yeung, H Martinez-Coria, RR Ager… - Brain research …, 2015 - Elsevier
… Position of the hidden platform MWM was changed for every … sexed matched 3xTg-AD mice
underwent behavior testing at … group, 3xTg-AD mice experienced significant reduction in Aβ …
underwent behavior testing at … group, 3xTg-AD mice experienced significant reduction in Aβ …
… -pituitary-adrenal (HPA) axis activity and anxiety-like behavior during aging: A test of the glucocorticoid cascade hypothesis in amyloidogenic APPswe/PS1dE9 mice
BN Harris, BR Roberts, GM DiMarco… - General and …, 2023 - Elsevier
… Our data suggest that despite Aβ accumulation in the … If results mirror those from 3xTgAD
mice under baseline … To determine if post-stressor behavior in the light–dark test changed with …
mice under baseline … To determine if post-stressor behavior in the light–dark test changed with …
Amyloid-beta induced neurotoxicity impairs cognition and adult hippocampal neurogenesis in a mouse model for Alzheimer's disease
… the association of Aβ-induced neurotoxicity with altered … We found a minor decrease in
DCX protein levels after Aβ … genesis in the triple transgenic AD mouse model (3xTg-AD) [64]. …
DCX protein levels after Aβ … genesis in the triple transgenic AD mouse model (3xTg-AD) [64]. …
Sex-and Neuropsychiatric-Dependent Circadian Alterations in Daily Voluntary Physical Activity Engagement and Patterns in Aged 3xTg-AD Mice
D Alveal-Mellado, L Castillo-Mariqueo… - International journal of …, 2022 - mdpi.com
… of the performance and behavioral effects of four weeks of … [49], including mice at 12 and
16 months of age at normal and AD-… the animal’s response to stressful/anxiogenic events [50]. …
16 months of age at normal and AD-… the animal’s response to stressful/anxiogenic events [50]. …
Adolescent binge alcohol enhances early Alzheimer's disease pathology in adulthood through proinflammatory neuroimmune activation
A Barnett, E David, A Rohlman, VD Nikolova… - Frontiers in …, 2022 - frontiersin.org
… We found that AIE increased levels of neurotoxic Aβ 1–42 in … found AIE did not significantly
alter APP gene expression (p = … persistent behavioral deficits caused by AIE in 3xTg-AD mice, …
alter APP gene expression (p = … persistent behavioral deficits caused by AIE in 3xTg-AD mice, …