Postsynaptic Protein Shank3a Deficiency Synergizes with Alzheimer's Disease Neuropathology to Impair Cognitive Performance in the 3xTg-AD Murine Model

O Landry, A François, MFOM Mi-Mba… - Journal of …, 2023 - Soc Neuroscience
… male and female 3xTg-AD mice modelling and tau … compared with 3xTg-AD mice with
normal Shank3 expression. … Detergent-soluble GFAP levels were not altered by Shank3a …

Chronic social and psychological stress impact select neuropathologies in the PS19 mouse model of tauopathy

CE Lyons, SI Graves, M Razzoli… - Psychosomatic …, 2024 - journals.lww.com
… the current gap in knowledge of the effects of social stress in this tauopathy mouse model. …
3xTgAD mice exhibit altered behavior and elevated after chronic mild social stress. …

The behavioral, pathological and therapeutic features of the triple transgenic Alzheimer's disease (3× Tg-AD) mouse model strain

S Tian, T Ye, X Cheng - Experimental Neurology, 2023 - Elsevier
… Although APP expression was not altered by age, monomers … in the hippocampus of a
3xTg-AD mouse were increasedlevel of low oligomer alone cannot alleviate the learning …

[HTML][HTML] Sex-dependent alterations in social behaviour and cortical synaptic activity coincide at different ages in a model of Alzheimer's disease

C Bories, MJ Guitton, C Julien, C Tremblay, M Vandal… - 2012 - journals.plos.org
… as or tau, increased with age, their association with social … -induced social hierarchy,
social recognition or social stress, … Taken together, our results show that 3xTg-AD mice present …

Aberrant Cortical Activity in 5xFAD Mice in Response to Social and Non-Social Olfactory Stimuli

F Kosel, MR Hartley, TB Franklin - Journal of Alzheimer's …, 2023 - content.iospress.com
… in 3xTg-AD mice, with transgenic (Tg) males exhibiting no … in the present study suggests
that these mice exhibit increased … suggesting that altered neural activity is due to -related …

[HTML][HTML] Impact of social isolation on the behavioral, functional profiles, and hippocampal atrophy asymmetry in dementia in times of coronavirus pandemic (COVID-19 …

A Muntsant, L Giménez-Llort - Frontiers in psychiatry, 2020 - frontiersin.org
… the impact of long-term isolation in male 3xTg-AD mice modeling … isolation in the AD pathology
as related to an increase in … -with-stress strategies were changed (from freeze) to flight …

[HTML][HTML] Environmental novelty exacerbates stress hormones and pathology in an Alzheimer's model

KE Stuart, AE King, CM Fernandez-Martos… - Scientific Reports, 2017 - nature.com
… , elevated stress levels, which may in turn have increased … APP/PS1 mice display
pathology from 4-5 months of age … novel enrichment objects (changed weekly). Housing …

[图书][B] Interleukin-6 trans-signaling in Alzheimer's disease. A study based on the Tg2576 and 3xTg-AD mouse models

A Escrig - 2019 - ddd.uab.cat
levels were diminished after the HFD treatment in comparison with mice fed with a
normal … There are evidences that altered insulin actions facilitate and tau accumulation. …

Chronic stress exacerbates tau pathology, neurodegeneration, and cognitive performance through a corticotropin-releasing factor receptor-dependent mechanism in a …

JC Carroll, M Iba, DA Bangasser… - Journal of …, 2011 - Soc Neuroscience
… , stress did not alter the levels of neprilysin, an degrading … mechanism of increased
in the absence of increased APP … the different mouse models (Tg2576 and PS19 vs 3xTg-AD), …

[HTML][HTML] Voluntary running does not reduce neuroinflammation or improve non-cognitive behavior in the 5xFAD mouse model of Alzheimer's disease

M Svensson, E Andersson, O Manouchehrian… - Scientific Reports, 2020 - nature.com
… Further, the inflammatory response is also altered in the AD … stress response in mice 34 , we
controlled for stress induction by … a nonsignificant trend towards increased plaques in the …