Inflammation, neurodegeneration and protein aggregation in the retina as ocular biomarkers for Alzheimer's disease in the 3xTg-AD mouse model
A Grimaldi, C Brighi, G Peruzzi, D Ragozzino… - Cell Death & …, 2018 - nature.com
… In addition to cognitive and behavioral deficits, sensorial … Recent findings also demonstrated
the alteration in the level … analyzed Aβ accumulation in retinal samples from 3xTg-AD mice …
the alteration in the level … analyzed Aβ accumulation in retinal samples from 3xTg-AD mice …
Prolonged running, not fluoxetine treatment, increases neurogenesis, but does not alter neuropathology, in the 3xTg mouse model of Alzheimer's disease
MW Marlatt, MC Potter, TA Bayer, H van Praag… - … and Neural Plasticity, 2013 - Springer
… in middle-age in the 3xTg AD mice. Such a design bears relevance … We here show that
despite the loss of the behavioral … also showed that amitriptyline increased Aβ deposition in the …
despite the loss of the behavioral … also showed that amitriptyline increased Aβ deposition in the …
[HTML][HTML] Translational modeling of psychomotor function in normal and AD-pathological aging with special concerns on the effects of social isolation
L Castillo-Mariqueo, L Giménez-Llort - Frontiers in Aging, 2021 - frontiersin.org
… the 3xTg-AD/ISO mice subgroup (n = 7) had a high motor … In particular, the grip has been
described as an alteration of … of places, 3xTg-AD mice exhibit these behaviors, which delays the …
described as an alteration of … of places, 3xTg-AD mice exhibit these behaviors, which delays the …
… That Modify Survival, Anxiety and Functional Profile (Physical Endurance and Motor Learning) of Old Male and Female 3xTg-AD Mice and NTg Mice with Normal …
L Castillo-Mariqueo, L Giménez-Llort - Biomedicines, 2022 - mdpi.com
… The results showed that 3xTg-AD mice show a significant … combination of emotional and
physical stress in a period of 5 h … spines and increase in the Aβ levels [50]. Additionally, the …
physical stress in a period of 5 h … spines and increase in the Aβ levels [50]. Additionally, the …
NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency
… , the 3xTgAD mouse, expresses mutant forms of human Aβ … the 3xTgAD mouse to generate
the 3xTgAD/Polβ +/− mice. … synapse function-related pathways changed in response to NR, …
the 3xTgAD/Polβ +/− mice. … synapse function-related pathways changed in response to NR, …
Long-term voluntary wheel running does not alter vascular amyloid burden but reduces neuroinflammation in the Tg-SwDI mouse model of cerebral amyloid …
LS Robison, DL Popescu, ME Anderson… - Journal of …, 2019 - Springer
… Tg-SwDI mice exhibited significant cerebral vascular Aβ pathology and increased … Tg-SwDI
sedentary mice exhibited reduced digging behavior and decreased exploration of Y-maze …
sedentary mice exhibited reduced digging behavior and decreased exploration of Y-maze …
Past to future: what animal models have taught us about Alzheimer's disease
AC Martini, S Forner, L Trujillo-Estrada… - Journal of …, 2018 - content.iospress.com
… 3xTg-AD mice by our research group have greatly advanced the AD field, as these mice
together promote the development of Aβ … state levels without altering Aβ degradation. This …
together promote the development of Aβ … state levels without altering Aβ degradation. This …
Chronic sleep restriction increases soluble hippocampal Aβ-42 and impairs cognitive performance
KN Brice, CW Hagen, JL Peterman, JW Figg… - … & Behavior, 2020 - Elsevier
… Unexpectedly, the sleep loss and any additional stress … or increased soluble Aβ in the brain
in eight-month-old 3xTgAD … did not alter body weight in adult C57BL/6 mice, chronic sleep …
in eight-month-old 3xTgAD … did not alter body weight in adult C57BL/6 mice, chronic sleep …
[HTML][HTML] Early-life environment influence on late-onset Alzheimer's disease
… lactation increases the level of Aβ peptides at the vascular level, and … in the brain of adult
mice, which leads to the alteration of the … In 3xTgAD mice, chronic social stress in adulthood, by …
mice, which leads to the alteration of the … In 3xTgAD mice, chronic social stress in adulthood, by …
Vulnerability and resilience to Alzheimer's disease: early life conditions modulate neuropathology and determine cognitive reserve
SL Lesuis, L Hoeijmakers, A Korosi… - Alzheimer's research & …, 2018 - Springer
… -mice), chronic early life stress increased soluble Aβ levels … at 4 months of age in 3xTg-AD
mice, an effect that was most … also show a failure to suppress their endogenous cortisol after …
mice, an effect that was most … also show a failure to suppress their endogenous cortisol after …