4nbutylresorcinol, a highly effective tyrosinase inhibitor for the topical treatment of hyperpigmentation

L Kolbe, T Mann, W Gerwat, J Batzer… - Journal of the …, 2013 - Wiley Online Library
… We were interested in evaluating the inhibition of skin pigmentation by well-known
compounds with skin-whitening activity like hydroquinone, arbutin kojic acid and 4-n-butylresorcinol, …

[HTML][HTML] Current clinical use of depigmenting agents

JW Shin, KC Park - Dermatologica Sinica, 2014 - Elsevier
… To date, the most effective topical treatment is a triple-… , 4-n-butylresorcinol effectively controlled
tyrosinase activity … an effect on pigmentation by inhibiting the activities of tyrosinase and …

[HTML][HTML] The efficacy and safety of 4-n-butylresorcinol 0.1% cream for the treatment of melasma: a randomized controlled split-face trial

SY Huh, JW Shin, JI Na, CH Huh, SW Youn… - Annals of …, 2010 - ncbi.nlm.nih.gov
… The most commercially available hypopigmenting agents include tyrosinase inhibitors as …
In conclusion, 4-n-butylresorcinol 0.1% cream showed significant efficacy as compared with …

Assessment of efficacy, safety, and tolerability of 4-n-butylresorcinol 0.3% cream: an Indian multicentric study on melasma

NT Madan Mohan, A Gowda, AK Jaiswal… - Clinical, cosmetic and …, 2016 - Taylor & Francis
… human tyrosinase inhibitory activity of 4-n-butylresorcinol … compound for the management
of pigmentation disorders. In … study, 4-n-butylresorcinol 0.3% cream was very effective and …

Efficacy of liposome‐encapsulated 4nbutylresorcinol and resveratrol cream in the treatment of melasma

SH Kwon, JH Yang, JW Shin, KC Park… - Journal of Cosmetic …, 2020 - Wiley Online Library
… have been shown to inhibit UV-induced pigmentation.9, 10 Since … tyrosinase levels, we
evaluated efficacy and safety of a … , 4nBR, a strong tyrosinase inhibitor, could work in combination …

4nbutylresorcinol enhances proteolytic degradation of tyrosinase in B16F10 melanoma cells

SJ Lee, YH Son, KB Lee, JH Lee… - … Journal of Cosmetic …, 2017 - Wiley Online Library
hyperpigmentation disorders and for whitening skin after … In clinical studies, topical application
of 4-n-butylresorcinol showed … 4-n-butylresorcinol is a well-known tyrosinase inhibitor 26. …

4nbutylresorcinol dissolving microneedle patch for skin depigmentation: a randomized, double‐blind, placebo‐controlled trial

S Kim, H Yang, M Kim, JH Baek, SJ Kim… - Journal of cosmetic …, 2016 - Wiley Online Library
… ) and who had facial hyperpigmentation were selected to test … to melanocytes efficiently
thereby inhibiting tyrosinase activity in … 4-n-butylresorcinol patch compared with traditional cream

Efficacy and safety of liposome‐encapsulated 4‐n‐butylresorcinol 0.1% cream for the treatment of melasma: A randomized controlled split‐face trial

SY Huh, JW SHIN, JI NA, CH HUH… - The Journal of …, 2010 - Wiley Online Library
tyrosinase inhibitors, which regulate the rate-limiting step of melanogenesis. 4-n-Butylresorcinol
because it has an inhibitory effect against tyrosinase and tyrosinase-related protein-1. …

The top 10 cosmeceuticals for facial hyperpigmentation

T Searle, F Al‐Niaimi, FR Ali - Dermatologic Therapy, 2020 - Wiley Online Library
… 50 000 other possible tyrosinase inhibitors tested. Thiamidol … be the most effective
combination in treating pigmentation in … treated melasma patients with twice daily 4-n-butylresorcinol

[HTML][HTML] Natural and bioinspired phenolic compounds as tyrosinase inhibitors for the treatment of skin hyperpigmentation: Recent advances

L Panzella, A Napolitano - Cosmetics, 2019 - mdpi.com
… of the most common approaches for control of skin pigmentation involves the inhibition of
tyrosinase, … This review focuses on the tyrosinase inhibition properties of a series of natural and …