… dermal extract70 and purified human laminin‐332 (LM332),14 … of both pemphigus diseases
and subepidermal AIBDs, with … proteins at the epidermal basement membrane zone (Table 1)…

… Association of the tetraspanin CD151 with the laminin-binding … The alpha 5 chain of type
IV collagen is the target of IgG … lonephritis and subepidermal blisters with autoantibodies to …

… ; and later epidermal and subepidermal blistering diseases by Dr. … collagen IV antibody is
positive at the basement membrane zone … In (c) We show direct immunofluorescence in case of …

… (2000): The alpha 5 chain of type IV collagen is the target of … pemphigoid bind the alpha
subunit of laminin 5. J. Invest. … of anti-laminin 5 antibodies induces subepidermal blisters in …

… states such as skin blistering disorders and cancers. We also … membrane (BM) that is rich in
Collagen IV and Laminin 332. … trans- membrane receptors, comprising of αβ subunits that link …

… disease as it is a cluster of many separate but related … Knockout of α6β4 or collagen-VII in
mice leads to similar blistering … on each of the Ln-332 subunits separately, as they have each …

… molecules including proteoglycans, collagen, and laminin isoforms (7). … of this antibody
targeting is subepidermal blistering, or … a2 subunits, suggesting that the G domain of the a3 chain …

… have been found to cause a blistering disease of the skin, … binding growth associated molecule
(HB-GAM) (20ug/ml) or laminin (… , the β1 integrin subunit and type IV collagen. Antibodies …

… similar to other autoimmune subepidermal bullous diseases. Although the diagnosis …
multiple laminin subunits who developed later autoantibodies to alpha-5 chain of type IV collagen …