[HTML][HTML] Detailed molecular mechanisms involved in drug-induced non-alcoholic fatty liver disease and non-alcoholic steatohepatitis: An update

LG Di Pasqua, M Cagna, C Berardo, M Vairetti… - Biomedicines, 2022 - mdpi.com
… is concomitant with low hepatic energy production, the drugs … the antiarrhythmic drugs
amiodarone and perhexiline; drugs that … Moreover, in this case report a decrease in triglyceride …

[HTML][HTML] Overview of therapeutic drug monitoring

JS Kang, MH Lee - The Korean journal of internal medicine, 2009 - ncbi.nlm.nih.gov
… age, weight, organ function, and concomitant drug therapy. When interpreting concentration
… prescribed, as can occur with amiodarone and perhexiline. If drug toxicity is suspected, then …

The prevalence of co‐prescription of clinically relevant CYP enzyme inhibitor and substrate drugs in community‐dwelling elderly Australians

KP Kerr, KE Mate, PJ Magin, J Marley… - Journal of clinical …, 2014 - Wiley Online Library
… For example, the concomitant treatment with a cytochrome P450 (CYP) 3A4 inhibitor and
a … , followed by quinine, sertraline, perhexiline, flecainide and amiodarone (Table 2). The …

[HTML][HTML] Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver

K Begriche, J Massart, MA Robin… - Journal of …, 2011 - Elsevier
Numerous investigations have shown that mitochondrial dysfunction is a major mechanism
of drug-induced liver injury, which involves the parent drug or a reactive metabolite …

Xenobiotic-induced hepatotoxicity: mechanisms of liver injury and methods of monitoring hepatic function

MG Sturgill, GH Lambert - Clinical chemistry, 1997 - academic.oup.com
… by perhexiline maleate and the antiarrhythmic agent … treated with amiodarone, although
overt liver injury is rare (102). … age), and concomitant exposure to drugs that alter cytochrome …

[HTML][HTML] The utility of HepG2 cells to identify direct mitochondrial dysfunction in the absence of cell death

L Kamalian, AE Chadwick, M Bayliss, NS French… - Toxicology in vitro, 2015 - Elsevier
… Surprisingly, the action of perhexiline, a known inhibitor of fatty acid oxidation, … amiodarone
were seen to behave in a fashion similar to rotenone; decreasing OCR with a concomitant

Perhexiline maleate induced lipidosis in human peripheral nerve and tissue culture: ultrastructural and biochemical changes

JJ Hauw, JM Mussini, JM Boutry, R Escourolle… - Clinical …, 1981 - Taylor & Francis
… We have performed concomitant biopsies of the superficial peroneal nerve, the peroneus …
with amiodarone and-possibly-chloroquine intoxications in the recently individualized group of …

Dronedarone, amiodarone and other antiarrhythmic drugs, and acute liver injuries: a case-referent study

L Grimaldi-Bensouda, H Wedemeyer, J Wiegand… - International Journal of …, 2018 - Elsevier
… Exposure to class III antiarrhythmic drugs was 4.0% in cases and 1.5% in controls, aOR =
3.6 (95% CI: 1.6–8.4). Associations with exposure to dronedarone and amiodarone were …

Metabolic modulator perhexiline corrects energy deficiency and improves exercise capacity in symptomatic hypertrophic cardiomyopathy

K Abozguia, P Elliott, W McKenna, TT Phan… - Circulation, 2010 - Am Heart Assoc
concomitant use of amiodarone or selective serotonin reuptake inhibitors (because of potential
drug interactions with perhexiline)… blinding of the study because perhexiline may lead to a …

[PDF][PDF] Uncoupling of rat and human mitochondria: a possible explanation for tacrine-induced liver dysfunction

A Berson, S Renault, P Letteron, MA Robin… - …, 1996 - academia.edu
drugs, including Rat liver mitochondria were isolated as previously deamiodarone and
perhexiline… ATP and Survival of Human Lymphocytes out concomitant ATP formation. This may be …