Addressing phenoconversion: the Achilles' heel of personalized medicine

RR Shah, RL Smith - British journal of clinical pharmacology, 2015 - Wiley Online Library
… in the non-users of amiodarone. In a warfarin pharmacogenetic … selected is the experience
with perhexiline in Australia. … therapy, especially when there is a likelihood of concomitant use …

[HTML][HTML] Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man

S Dragovic, NPE Vermeulen, HH Gerets, PG Hewitt… - Archives of …, 2016 - Springer
… ; amiodarone, perhexiline, and troglitazone on causing lysosomal impairment and bosentan,
diclofenac, nefazodone, perhexiline, … steatosis, concomitant macrovacuolar steatosis and …

Hepatotoxicity by drugs

AC Paniagua, P Amariles - … and Adverse Effects of Drugs …, 2017 - books.google.com
… factors such as concomitant administration of drugs or herbal remedies, alcohol consumption,
… present, RUCAM allows discern when confusing factors or concomitant drugs are present. …

Modulation of myocardial energetics: emerging evidence for a therapeutic target in cardiovascular disease

DA Morrow, MM Givertz - Circulation, 2005 - Am Heart Assoc
… The salutary effects of perhexiline on skeletal muscle metabolism also suggest peripheral …
(eg, with amiodarone and selective serotonin reuptake inhibitors), and concomitant hepatic or …

Simvastatin‐induced myopathy, the role of interaction with diltiazem and genetic predisposition

M Hu, VWL Mak, B Tomlinson - Journal of clinical pharmacy …, 2011 - Wiley Online Library
… risk of myopathy was identified with concomitant use of amiodarone, which is known to inhibit
… taking amiodarone and this report prompted a warning about the interaction of amiodarone

[HTML][HTML] The utility of HepaRG cells for bioenergetic investigation and detection of drug-induced mitochondrial toxicity

L Kamalian, O Douglas, CE Jolly, J Snoeys, D Simic… - Toxicology in Vitro, 2018 - Elsevier
… Pioglitazone and amiodarone were excluded from this study due to inconsistent solubility
in … and perhexiline showed decrease of SRC with or without ALR, but with concomitant

Metabolic therapeutics in angina pectoris: history revisited with perhexiline

S Inglis, S Stewart - European Journal of Cardiovascular …, 2006 - journals.sagepub.com
… agent, perhexiline maleate. This review aims to update the cardiac nurse with knowledge
to manage the care a patient receiving perhexiline maleate treatment and provide a brief …

Mitochondrial involvement in drug-induced liver injury

D Pessayre, A Mansouri, A Berson, B Fromenty - Adverse drug reactions, 2010 - Springer
… In isolated rat hepatocytes treated with amiodarone, perhexiline, or
diethylaminoethoxyhexestrol… The concomitant administration of phenytoin and carbamazepine can …

Genetic polymorphism and toxicology—with emphasis on cytochrome p450

I Johansson, M Ingelman-Sundberg - Toxicological sciences, 2011 - academic.oup.com
Case report: A woman who had been on warfarin treatment for … combination of acenocoumarol
therapy and concomitant use of … effect and the toxicity of perhexiline has been elucidated. …

Hepatocellular toxicity and pharmacological effect of amiodarone and amiodarone derivatives

KM Waldhauser, M Török, HR Ha, U Thomet… - Journal of pharmacology …, 2006 - ASPET
The aim of this work was to compare hepatocellular toxicity and pharmacological activity of
amiodarone (2-n-butyl-3-[3,5 diiodo-4-diethylaminoethoxybenzoyl]-benzofuran; B2-O-Et-N-…