Simvastatin‐induced myopathy, the role of interaction with diltiazem and genetic predisposition

M Hu, VWL Mak, B Tomlinson - Journal of clinical pharmacy …, 2011 - Wiley Online Library
… risk of myopathy was identified with concomitant use of amiodarone, which is known to inhibit
… taking amiodarone and this report prompted a warning about the interaction of amiodarone

Genetic polymorphism and toxicology—with emphasis on cytochrome p450

I Johansson, M Ingelman-Sundberg - Toxicological sciences, 2011 - academic.oup.com
Case report: A woman who had been on warfarin treatment for … combination of acenocoumarol
therapy and concomitant use of … effect and the toxicity of perhexiline has been elucidated. …

Mitochondrial involvement in drug-induced liver injury

D Pessayre, A Mansouri, A Berson, B Fromenty - Adverse drug reactions, 2010 - Springer
… In isolated rat hepatocytes treated with amiodarone, perhexiline, or
diethylaminoethoxyhexestrol… The concomitant administration of phenytoin and carbamazepine can …

Disruption of Hepatic Lipid Homeostasis in Mice after Amiodarone Treatment Is Associated with Peroxisome Proliferator-Activated Receptor-αTarget Gene Activation

TC McCarthy, PT Pollak, EA Hanniman… - Journal of Pharmacology …, 2004 - ASPET
… the livers of amiodarone-treated mice, concomitant with an … treated with increasing
concentrations of amiodarone and assayed for cell viability by the MTT assay. Amiodarone treatment

Amiodarone neuropathy

A Martinez-Arizala, SM Sobol, GE McCarty… - Neurology, 1983 - AAN Enterprises
… modalities, usually with a concomitant sensory gait ataxia (… neuropathy 3 years after
treatment with amiodarone, 400 mg … similar to those present in perhexiline maleate intoxication. …

Drug‐induced liver disease

S Chitturi, GC Farrell - Schiff's diseases of the liver, 2011 - Wiley Online Library
… as concomitant medication, pro… drugs (eg, perhexiline maleate [107] and amiodarone [108]);
the term “drug-induced steatohepatitis” is now preferred to “secondary NASH”. Among drugs

[HTML][HTML] Drug-Induced Fatty Liver Disease (DIFLD): A Comprehensive Analysis of Clinical, Biochemical, and Histopathological Data for Mechanisms Identification and …

E López-Pascual, I Rienda, J Perez-Rojas… - International Journal of …, 2024 - mdpi.com
… In certain individuals, drug-induced steatosis is often accompanied by concomitant injury …
occasionally reported for drugs such as amiodarone, perhexiline, and didanosine [13,37]. …

[PDF][PDF] Drug-induced hepatic injury

BHC Stricker, P Spoelstra - 1992 - core.ac.uk
… accurately and that several adverse effects can be studied concomitantly. Moreover … eg
neuropathy due to perhexiline or amiodarone, skin discoloration by amiodarone). Immunoallergic …

[HTML][HTML] Inhibition of mitochondrial fatty acid oxidation in drug-induced hepatic steatosis

B Fromenty - Liver Research, 2019 - Elsevier
perhexiline and pirprofen were withdrawn after marketing. (ii) Drugs such as amiodarone and
perhexiline … (iii) For some drugs including APAP, 40 , 41 L-asparaginase, 42 erythromycin, …

Hepatotoxicity of cardiovascular and antidiabetic drugs

FA de la Iglesia, JR Haskins… - Drug-Induced liver …, 2003 - api.taylorfrancis.com
… Long-term amiodarone treatment may evoke mild hepatic lesions or more … with perhexiline
maleate and bezafibrate (235). … acid therapy: a case report. Am J Med Sci 1969; 258:94–99. …