… Thirteen patients were treated to prevent the disease in kidney graft. Patients with aHUS in
… It can be argued that children may have different pharmacokinetics compared with adults. …

… For logistical reasons, intradermal testing was done 2 weeks later and was positive with
a … This case illustrates how rapid drug desensitization can help a young child continue first-line …

… Eculizumab, a monoclonal antibody, binds to C5 to prevent … Reports of aHUS cases and
use of eculizumab significantly … to the precedent for unknown reasons. Although significant …

… For adult patients and children weighing ˃40 kg, eculizumab … of eculizumab treatment
dictate that one should aim to avoid … in this study for logistical reasons. Although one may argue …

… to prevent premature apheresis removal of rituximab, which was added as a salvage agent
for lupus nephritis)10 with plan to convert to eculizumab … effects of eculizumab in a child with …

… to their illness during the acute phase, nearly half develop end-… Study 3 was a retrospective
analysis involving 19 children with … who discontinued eculizumab therapy for various reasons …

… for various reasons, including … eculizumab following the onset of aHUS, it was discontinued
in 14 patients who were monitored closely during follow-up for the signs of recurrence. End-…

… , thrombotic microangiopathy, and subsequent end‐organ damage 1. It is distinguished from
typical hemolytic uremic syndrome (HUS) in that it lacks coexisting disease such as Shiga‐…

… in the pathogenesis of atypical hemolytic uremic syndrome. … reasoning, and adaptive behavior
were comparable to their … 33 children from 15 centers in France treated with eculizumab …

… people who were caring for a child with aHUS. Patients had … One of the main reasons they
preferred ravulizumab was that … This approach was taken to prevent unauthorized access to …