A Heat-Killed Cryptococcus Mutant Strain Induces Host Protection against Multiple Invasive Mycoses in a Murine Vaccine Model

Y Wang, K Wang, JA Masso-Silva, A Rivera, C Xue - MBio, 2019 - Am Soc Microbiol
protection against Candida albicans. Thus, our data suggest that the heat-killed fbp1Δ strain
… a suitable vaccine candidate against cryptococcosis and other invasive fungal infections in …

Development of a Heat-Killed fbp1 Mutant Strain as a Therapeutic Agent To Treat Invasive Cryptococcus Infection

Y Wang, K Wang, A Rivera, C Xue - Microbiology Spectrum, 2023 - Am Soc Microbiol
… for vaccine-induced protection against homologous challenge and … to elicit robust host
protection against cryptococcosis. … Several mutant strains, such as the strain overexpressing the …

Three Models of Vaccination Strategies Against Cryptococcosis in Immunocompromised Hosts Using Heat-Killed Cryptococcus neoformans Δsgl1

TG Normile, M Del Poeta - Frontiers in Immunology, 2022 - frontiersin.org
… agent of cryptococcosis, a life-threatening invasive fungal … conferred complete host protection
to the WT strain even … To assess the longevity of the vaccine-induced host protection, we …

Immunization with a heat-killed prm1 deletion strain protects the host from Cryptococcus neoformans infection

C Li, Y Meng, H Li, W Du, X Gao, C Suo… - Emerging Microbes & …, 2023 - Taylor & Francis
… The wild-type and mutant strains were heat killed at 99C for 5 min, and supernatants were
against invasive cryptococcosis, and both Th1 and Th17 immune responses can be induced

Protection against Cryptococcosis by Using a Murine Gamma Interferon-Producing Cryptococcus neoformans Strain

FL Wormley Jr, JR Perfect, C Steele… - Infection and …, 2007 - Am Soc Microbiol
… of host immune responses to invasive cryptococcal infection. However, … therapy alone have
failed to induce complete clearance of C. … neoformans strain H99 or H99-γ or heat-killed C. …

… response induced by mucosal immunization with heat-killed Cryptococcus neoformans yeast cells and analysis of a non-human primate model of cryptococcosis

JP McCracken - 2006 - search.proquest.com
… neoformans could be induced by mucosal immunization using a mutant of E. coli heat-labile …
century produced several published clinical cases of cryptococcosis affecting several organs…

Immune evasion by Cryptococcus gattii in vaccinated mice coinfected with C. neoformans

MM Hester, D Carlson, JK Lodge, SM Levitz… - Frontiers in …, 2024 - frontiersin.org
… of protection for these strains remains unclear, each induced a … , cryptococcal mutant strain:
Deletion of all three cryptococcal … and the heat-killed WT strain, which are inoculated directly …

Cryptococcus neoformans chitin synthase 3 plays a critical role in dampening host inflammatory responses

CR Hole, WC Lam, R Upadhya, JK Lodge - MBio, 2020 - Am Soc Microbiol
Cryptococcus neoformans infections are significant causes of morbidity and mortality among
AIDS patients and the third most common invasive … chose to use heat-killed fungi to control …

Lipid flippase subunit Cdc50 mediates drug resistance and virulence in Cryptococcus neoformans

W Huang, G Liao, GM Baker, Y Wang, R Lau, P Paderu… - MBio, 2016 - Am Soc Microbiol
… Our results showed that all three mutant strains had levels of … strains with YPD, fresh DME,
fresh DME with 10% heat-killed fetal … expression is specifically induced during interaction with …

Dendritic cell-based immunization ameliorates pulmonary infection with highly virulent Cryptococcus gattii

K Ueno, Y Kinjo, Y Okubo, K Aki, M Urai… - Infection and …, 2015 - Am Soc Microbiol
Cryptococcus neoformans and Cryptococcus gattii causes life-… mutants have been
successfully used as vaccines (29), vaccination using heat-killed R265 or heat-killed Δcap60 strain