… is markedly overexpressed in non-small-cell lung cancer tissues; … We developed this clinical
trial to test if the combination of … biology of SCLC and incorporation of target-based biologic …

… Subsequently, gefitinib was combined with celecoxib to … There have been many studies on
the biology of EGFR signal transduction … Erlotinib versus standard chemotherapy as first-line …

… Gy to a total dose of 45 Gy yields a biologic dose similar to 60 … Laio et al 23 conducted a
phase I study of celecoxib and RT … not show the combination to be superior to erlotinib alone in …

… The maximum tolerated dose of erlotinib with celecoxib 400 … with advanced metastatic
non–small cell lung cancer when … Our rationale for combining celecoxib and erlotinib stems …

… Further studies are required to assess the usefulness of this biomarker to identify … a phase
1 trial focused on defining the optimal biologic dose of celecoxib in combination with erlotinib, …

… study aimed to identify the radiosensitizing effect of celecoxib… combination with radiotherapy
in non-small-cell lung cancer (… Gy/min for 1 min; The maximum dosage of 6 Gy was selected …

… trials and treatments have focused mainly on non-small cell … celecoxib in combination
with EGFR TKI (erlotinib). This … for non-small cell lung cancer: a phase II study with biological …

… We show that combined treatment with gefitinib and celecoxib can decrease Rad51 … trials
to determine the optimal biological dose of celecoxib combined with erlotinib in advanced …

… tolerated dose (MTD) and toxicity profile of the combination of … In initial phase II studies,
patients with non-small cell lung cancer (… , and to perform additional biologic correlative studies. …

… of a prospective phase II study using celecoxib in combination with … (7), which had used a
combination of apricoxib with erlotinib, … a better understanding the biology of COX-2 in NSCLC. …