New targets for non-small-cell lung cancer therapy

M Alvarez, E Roman, ES Santos… - Expert review of …, 2007 - Taylor & Francis
… This study concluded that erlotinib in combination with … In a Phase II trial, celecoxib was
combined with carboplatin … 13 randomized Phase III clinical trials where the biological

Cyclooxygenase-2 (COX-2) as a predictive marker for the use of COX-2 inhibitors in advanced nonsmall-cell lung cancer

MJ Edelman, L Hodgson, X Wang… - Journal of Clinical …, 2012 - ascopubs.org
phase II trial that combined apricoxib (a COX-2 inhibitor that is similar to celecoxib) and
erlotinib in patients with recurrent nonsmall… article2 that the celecoxib dose may be inadequate …

Combining targeted therapies and drugs with multiple targets in the treatment of NSCLC

P Maione, C Gridelli, T Troiani, F Ciardiello - The Oncologist, 2006 - academic.oup.com
… clinical trials of targeted agents in non-small cell lung cancer (… phase II trial is planned
comparing erlotinib plus celecoxib … , and optimal biological dose in patients with advanced solid …

Targeted therapies for nonsmall cell lung cancer: an evolving landscape

SK Pal, RA Figlin, K Reckamp - Molecular cancer therapeutics, 2010 - AACR
… valuable information about the biology of lung cancer. Outside of … phase I-II study is exploring
the combination of erlotinib and … , in a randomized phase II trial comparing celecoxib with or …

Select clinical trials of erlotinib (OSI-774) in nonsmall-cell lung cancer with emphasis on phase III outcomes

LMB Fuster, AB Sandler - Clinical lung cancer, 2004 - Elsevier
… on how these mutations affect the biology of lung cancer, it is possible that we may be … study
(1) erlotinib plus chemotherapy in combination with radiation and (2) erlotinib plus celecoxib

The cancer pain related factors affected by celecoxib together with cetuximab in head and neck squamous cell carcinoma

Y Yang, J Yan, Y Huang, H Xu, Y Zhang, R Hu… - Biomedicine & …, 2015 - Elsevier
… of C225 and low-dose celecoxib may result in a more … determine the levels of PGE 2 in
CAL-27 and Fadu cells treated with … and erlotinib) for NSCLC and head and neck cancer [35], [36]…

[PDF][PDF] Non small cell lung cancer

W Franklin - 1986 - plataformadeoncologia.com
Celecoxib optimal biological dose 600 mg bid (maximal urinary decrease of PGE-M without
toxicity) + Erlotinib … ICH determination of RRM1 protein (involved in nucleotide excision repair…

The role of targeted therapy in non-small cell lung cancer

P Maione, A Rossi, G Airoma, C Ferrara… - Critical reviews in …, 2004 - Elsevier
… aimed at determining the biologically-optimal dose may be … NSCLC combining erlotinib
with polychemotherapy (carboplatin … of a phase II trial of docetaxel plus celecoxib in pretreated …

Targeted therapies for nonsmall cell lung cancer

J Spicer, P Harper - International journal of clinical practice, 2005 - Wiley Online Library
… An increased understanding of the biology of lung cancer has … , gefitinib and erlotinib were
combined with chemotherapy early in … administered with the COX-2 inhibitor celecoxib (22). A …

Gemcitabine plus celecoxib in patients with advanced or metastatic pancreatic adenocarcinoma: results of a phase II trial

T Dragovich, H Burris III, P Loehrer… - American journal of …, 2008 - journals.lww.com
… survival, 6.37 months for erlotinib arm versus 5.91 months for … phase II study evaluated
clinical activity of a combination of … In a phase I trial, in patients with nonsmall-cell lung cancer, …