New targets for non-small-cell lung cancer therapy

M Alvarez, E Roman, ES Santos… - Expert review of …, 2007 - Taylor & Francis
… This study concluded that erlotinib in combination with … In a Phase II trial, celecoxib was
combined with carboplatin … 13 randomized Phase III clinical trials where the biological

[PDF][PDF] Non small cell lung cancer

W Franklin - 1986 - plataformadeoncologia.com
Celecoxib optimal biological dose 600 mg bid (maximal urinary decrease of PGE-M without
toxicity) + Erlotinib … ICH determination of RRM1 protein (involved in nucleotide excision repair…

Targeted therapies for nonsmall cell lung cancer

J Spicer, P Harper - International journal of clinical practice, 2005 - Wiley Online Library
… An increased understanding of the biology of lung cancer has … , gefitinib and erlotinib were
combined with chemotherapy early in … administered with the COX-2 inhibitor celecoxib (22). A …

Select clinical trials of erlotinib (OSI-774) in nonsmall-cell lung cancer with emphasis on phase III outcomes

LMB Fuster, AB Sandler - Clinical lung cancer, 2004 - Elsevier
… on how these mutations affect the biology of lung cancer, it is possible that we may be … study
(1) erlotinib plus chemotherapy in combination with radiation and (2) erlotinib plus celecoxib

The cancer pain related factors affected by celecoxib together with cetuximab in head and neck squamous cell carcinoma

Y Yang, J Yan, Y Huang, H Xu, Y Zhang, R Hu… - Biomedicine & …, 2015 - Elsevier
… of C225 and low-dose celecoxib may result in a more … determine the levels of PGE 2 in
CAL-27 and Fadu cells treated with … and erlotinib) for NSCLC and head and neck cancer [35], [36]…

COX-2 inhibitors, a potential synergistic effect with antineoplastic drugs in lung cancer

W Hohenforst-Schmidt, K Domvri, N Zogas… - Oncomedicine, 2017 - oncm.org
… A phase I trial to determine the optimal biological dose of celecoxib when combined with
erlotinib in advanced non-small cell lung cancer. Clinical …

The role of targeted therapy in non-small cell lung cancer

P Maione, A Rossi, G Airoma, C Ferrara… - Critical reviews in …, 2004 - Elsevier
… aimed at determining the biologically-optimal dose may be … NSCLC combining erlotinib
with polychemotherapy (carboplatin … of a phase II trial of docetaxel plus celecoxib in pretreated …

Novel small molecule EGFR inhibitors as candidate drugs in non-small cell lung cancer

R Berardi, M Santoni, F Morgese… - OncoTargets and …, 2013 - Taylor & Francis
… et al performed a Phase II trial of gefitinib plus celecoxib, a … of combining erlotinib and c-Met
TKIs, the combination of … versus erlotinib in patients with advanced non-small-cell lung cancer

Current status of and future strategies for multimodality treatment of unresectable stage III nonsmall cell lung cancer

RM Huber, M Reck, M Thomas - European Respiratory Journal, 2013 - Eur Respiratory Soc
… A phase I study evaluated erlotinib alongside two … with locally advanced NSCLC who received
celecoxib at doses up to … enhanced by cisplatin in stage III non-small cell lung cancer. Int J …

Therapeutic effects of repurposed therapies in non-small cell lung cancer: what is old is new again

A Saxena, D Becker, I Preeshagul, K Lee, E Katz… - The …, 2015 - academic.oup.com
… The other is a phase I study evaluating rosuvastatin with erlotinib in patient … phase II trial
evaluating celecoxib 400 mg oral bid in combination with gefitinib 250 mg oral daily in advanced-…