Potassium channels as a potential therapeutic target for trigeminal neuropathic and inflammatory pain

M Takeda, Y Tsuboi, J Kitagawa… - … pain, 2011 - journals.sagepub.com
rats to study the trigeminal nervous system [48,49]. Temporomandibular joint (TMJ)
inflammation … satellite-glial cells via activation of neurokinin 1 receptor (SP release from small …

Neural mechanisms of temporomandibular joint and masticatory muscle pain: a possible role for peripheral glutamate receptor mechanisms

DK Lam, BJ Sessle, BE Cairns… - Pain Research and …, 2005 - Wiley Online Library
… in a paracrine fashion to activate NMDA receptors of adjacent … and substance P in dorsal
root ganglion neurons of the rat … Evidence for the interaction of glutamate and NK1 receptors

Final Accepted Version

M Takeda, T Tanimoto, M Ikeda, M Nasu, J Kadoi… - 2004 - journals.physiology.org
… that temporomandibular joint (TMJ) inflammation alters the … of mRNA for NK1 receptors on
the trigeminal ganglia was … resistance after substance P (0.1 µM) application in inflamed rats. …

Glial cell line-derived neurotrophic factor modulates the excitability of nociceptive trigeminal ganglion neurons via a paracrine mechanism following inflammation

M Takeda, M Takahashi, N Hara… - Brain, behavior, and …, 2013 - Elsevier
… messengers, such as ATP, substance P (SP) and calcitonin … paracrine mechanisms in the
sensory ganglia contribute to … by mechanical stimulation in CFA-induced inflamed rats were …

Toll-like receptor 4 signaling in trigeminal ganglion neurons contributes tongue-referred pain associated with tooth pulp inflammation

K Ohara, K Shimizu, S Matsuura, B Ogiso… - Journal of …, 2013 - Springer
Substance P or calcitonin gene-related peptide is known to … (TG) neurons following
temporomandibular joint inflammation … tongue in M1TP inflamed rats compared with sham rats. …

Role of neuropeptides in orofacial pain: A literature review

J Wang, X Liu, J Gou, J Deng, M Li… - Journal of Oral …, 2024 - Wiley Online Library
pain encompasses dental pain, temporomandibular joint (… A mice experiment demonstrated
that CGRP upregulated … C; SP, substance P; TRPM3, transient receptor potential cation …

Neuroimmune and Systemic Manifestations of Neuroinflammation in the Temporomandibular Joint and Related Disorders

A Barkhordarian, F Chiappelli… - Temporomandibular Joint …, 2018 - Springer
… CGRP into the TMJ capsule of rats will result in an increased … GG through a paracrine secretion
mechanism of substance P … include substance P acting on the neurokinin 1 receptor (NK1

Role of Neurotrophins in Orofacial Pain Modulation: A Review of the Latest Discoveries

F Bonomini, G Favero, S Castrezzati… - International journal of …, 2023 - mdpi.com
allodynia of the inflamed temporomandibular joint (TMJ) in … in an inflammatory soup-induced
trigeminal allodynia in a rat … upregulates TrkB through a paracrine/autocrine mechanism, …

[PDF][PDF] Neurophysiology of orofacial pain

K Iwata, M Takeda, SB Oh… - … Oral Medicine, Springer …, 2017 - researchgate.net
… and NK1 receptors in Vc and C1-C2 nociceptive neurons. Further, … a paracrine mechanism
via substance P (SP)-neurokinin 1(… activity in rats with persistent temporomandibular joint and …

Contribution of activated interleukin receptors in trigeminal ganglion neurons to hyperalgesia via satellite glial interleukin-1β paracrine mechanism

M Takeda, M Takahashi, S Matsumoto - Brain, behavior, and immunity, 2008 - Elsevier
… by mechanical and pinch stimuli in control and inflamed rats. … that temporomandibular joint
(TMJ) inflammation increased the … activation of NK1 receptors (SP release from small TRG …